Title | Clinical and Imaging Determinants of Neurocognitive Disorders in Post-Acute COVID-19 Patients with Cognitive Complaints. |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Andriuta, D, Si-Ahmed, C, Roussel, M, Constans, J-M, Makki, M, Aarabi, A, Basille, D, Andrejak, C, Godefroy, O |
Journal | J Alzheimers Dis |
Volume | 87 |
Issue | 3 |
Pagination | 1239-1250 |
Date Published | 2022 |
ISSN | 1875-8908 |
Keywords | Cognition, COVID-19, Humans, Leukoaraiosis, Magnetic Resonance Imaging, Neurocognitive Disorders, Neuropsychological Tests, Oxygen, White Matter |
Abstract | BACKGROUND: Neurocognitive disorders (NCDs) are a part of the post-acute coronavirus disease (COVID-19) syndrome. No study has specifically evaluated NCDs in post-acute COVID-19 patients with cognitive complaints or their MRI determinants. OBJECTIVE: To characterize NCDs in post-acute COVID-19 patients with cognitive complaints. The secondary objectives were to assess their clinical and MRI determinants. METHODS: We included 46 patients with a post-acute COVID-19 cognitive complaint referred to the Amiens University Hospital Memory Center. They underwent a neuropsychological assessment and 36 had cerebral MRI. The G3 overall summary score was the sum of the mean z scores for the executive function, language, and action speed domains. Neuropsychological profiles were compared in a general linear model. Clinical determinants were analyzed by stepwise linear regression. White matter hyperintensities (WMH) masks were analyzed using parcel-based WMH symptom mapping to identify the locations of WMHs associated with cognitive performance. RESULTS: Repeated ANOVA showed a group effect (p = 0.0001) due to overall lower performance for patients and a domain effect (p = 0.0001) due to a lower (p = 0.007) action speed score. The G3 overall summary score was significantly associated with solely the requirement for oxygen (R2 = 0.319, p = 0.031). WHMs were associated with the G3 overall summary score in the following structures, all right-sided (p < 0.01): superior frontal region, postcentral region, cingulum, cortico-spinal tract, inferior longitudinal fasciculus, internal capsule, and posterior segment of the arcuate fasciculus. CONCLUSION: Post-acute COVID-19 patients with cognitive complaints had NCD, with prominent action slowing, significantly associated with the acute phase oxygen requirement and a right-sided WMH structure pattern. |
DOI | 10.3233/JAD-215506 |
Alternate Journal | J Alzheimers Dis |
PubMed ID | 35431242 |