| Title | Refining Risk for Alzheimer's Disease Among Heterozygous APOEɛ4 Carriers. |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Patel, S, Wei, J, Shi, Z, Rifkin, AS, S Zheng, L, Gelfman, E, Duggan, D, Helfand, BT, Hulick, PJ, Xu, J |
| Journal | J Alzheimers Dis |
| Volume | 94 |
| Issue | 2 |
| Pagination | 483-489 |
| Date Published | 2023 |
| ISSN | 1875-8908 |
| Keywords | Alzheimer Disease, Apolipoprotein E4, Apolipoproteins E, Heterozygote, Homozygote, Humans |
| Abstract | In a large population-based cohort, we show not all heterozygous APOEɛ4 carriers are at increased risk for Alzheimer's disease (AD); a significantly higher AD proportion was only found for ɛ3/ɛ4, not ɛ2/ɛ4. Among ɛ3/ɛ4 carriers (24% in the cohort), the AD proportion differed considerably by polygenic risk score (PRS). In particular, the AD proportion was lower than the entire cohort for subjects in the bottom 20-percentile PRS and was higher than that of homozygous ɛ4 carriers for subjects at the top 5th-percentile PRS. Family history was no longer a significant predictor of AD risk after adjusting APOE and PRS. |
| DOI | 10.3233/JAD-230156 |
| Alternate Journal | J Alzheimers Dis |
| PubMed ID | 37334598 |
