Journal of Alzheimer's Disease
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Home > The Inflammation-Induced Dysregulation of Reelin Homeostasis Hypothesis of Alzheimer's Disease.

TitleThe Inflammation-Induced Dysregulation of Reelin Homeostasis Hypothesis of Alzheimer's Disease.
Publication TypeJournal Article
Year of Publication2024
AuthorsReive, BS, Lau, V, Sánchez-Lafuente, CL, Henri-Bhargava, A, Kalynchuk, LE, Tremblay, M-È, Caruncho, HJ
JournalJ Alzheimers Dis
Volume100
Issue4
Pagination1099-1119
Date Published2024
ISSN1875-8908
KeywordsAlzheimer Disease, Animals, Cell Adhesion Molecules, Neuronal, Extracellular Matrix Proteins, Homeostasis, Humans, Inflammation, Nerve Tissue Proteins, Reelin Protein, Serine Endopeptidases, Signal Transduction
Abstract

Alzheimer's disease (AD) accounts for most dementia cases, but we lack a complete understanding of the mechanisms responsible for the core pathology associated with the disease (e.g., amyloid plaque and neurofibrillary tangles). Inflammation has been identified as a key contributor of AD pathology, with recent evidence pointing towards Reelin dysregulation as being associated with inflammation. Here we describe Reelin signaling and outline existing research involving Reelin signaling in AD and inflammation. Research is described pertaining to the inflammatory and immunological functions of Reelin before we propose a mechanism through which inflammation renders Reelin susceptible to dysregulation resulting in the induction and exacerbation of AD pathology. Based on this hypothesis, it is predicted that disorders of both inflammation (including peripheral inflammation and neuroinflammation) and Reelin dysregulation (including disorders associated with upregulated Reelin expression and disorders of Reelin downregulation) have elevated risk of developing AD. We conclude with a description of AD risk in various disorders involving Reelin dysregulation and inflammation.

DOI10.3233/JAD-240088
Alternate JournalJ Alzheimers Dis
PubMed ID38995785
PubMed Central IDPMC11380287
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Source URL: https://www.j-alz.com/content/inflammation-induced-dysregulation-reelin-homeostasis-hypothesis-alzheimers-disease