| Title | Amnestic Syndrome in Memory Clinics: Similar Morphological Brain Patterns in Older Adults with and without Alzheimer's Disease. |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Lalive, HM, Griffa, A, Carlier, S, Nasuti, M, Di Noto, T, Maréchal, B, Rouaud, O, Allali, G |
| Journal | J Alzheimers Dis |
| Volume | 100 |
| Issue | 1 |
| Pagination | 333-343 |
| Date Published | 2024 |
| ISSN | 1875-8908 |
| Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Amnesia, Amyloid beta-Peptides, Biomarkers, Brain, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Mental Recall, Neuropsychological Tests, Organ Size |
| Abstract | BACKGROUND: Amnestic syndrome of the hippocampal type (ASHT) in Memory Clinics is a presentation common to Alzheimer's disease (AD). However, ASHT can be found in other neurodegenerative disorders. OBJECTIVE: To compare brain morphometry including hippocampal volumes between amnestic older adults with and without AD pathology and investigate their relationship with memory performance and cerebrospinal fluid (CSF) biomarkers. METHODS: Brain morphometry of 92 consecutive patients (72.5±6.8 years old; 39% female) with Free and Cued Selective Recall Reminding Test (FCSRT) total recall < 40/48 was assessed with an automated algorithm and compared between AD and non-AD patients, as defined by CSF biomarkers. RESULTS: AD and non-AD patients presented comparable brain morphology. Total recall was associated to hippocampal volume irrespectively from AD pathology. CONCLUSIONS: Brain morphometry, including hippocampal volumes, is similar between AD and non-AD older adults with ASHT evaluated in a Memory Clinic, underlying the importance of using molecular biomarkers for the diagnosis of AD. |
| DOI | 10.3233/JAD-240026 |
| Alternate Journal | J Alzheimers Dis |
| PubMed ID | 38875037 |
