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Home > Psychosis in Neurodegenerative Dementias: A Systematic Comparative Review.

TitlePsychosis in Neurodegenerative Dementias: A Systematic Comparative Review.
Publication TypeJournal Article
Year of Publication2024
AuthorsCressot, C, Vrillon, A, Lilamand, M, Francisque, H, Méauzoone, A, Hourregue, C, Dumurgier, J, Marlinge, E, Paquet, C, Cognat, E
JournalJ Alzheimers Dis
Volume99
Issue1
Pagination85-99
Date Published2024
ISSN1875-8908
KeywordsAlzheimer Disease, Delusions, Dementia, Frontotemporal Dementia, Humans, Lewy Body Disease, Neurodegenerative Diseases, Psychotic Disorders
Abstract

BACKGROUND: Psychosis, characterized by delusions and/or hallucinations, is frequently observed during the progression of Alzheimer's disease (AD) and other neurodegenerative dementias (ND) (i.e., dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD)) and cause diagnostic and management difficulties.

OBJECTIVE: This review aims at presenting a concise and up-to-date overview of psychotic symptoms that occur in patients with ND with a comparative approach.

METHODS: A systematic review was conducted following the PRISMA guidelines. 98 original studies investigating psychosis phenotypes in neurodegenerative dementias were identified (40 cohort studies, 57 case reports).

RESULTS: Psychosis is a frequently observed phenomenon during the course of ND, with reported prevalence ranging from 22.5% to 54.1% in AD, 55.9% to 73.9% in DLB, and 18% to 42% in FTD. Throughout all stages of these diseases, noticeable patterns emerge depending on their underlying causes. Misidentification delusions (16.6-78.3%) and visual hallucinations (50-69.6%) are frequently observed in DLB, while paranoid ideas and somatic preoccupations seem to be particularly common in AD and FTD, (respectively 9.1-60.3% and 3.10-41.5%). Limited data were found regarding psychosis in the early stages of these disorders.

CONCLUSIONS: Literature data suggest that different ND are associated with noticeable variations in psychotic phenotypes, reflecting disease-specific tendencies. Further studies focusing on the early stages of these disorders are necessary to enhance our understanding of early psychotic manifestations associated with ND and help in differential diagnosis issues.

DOI10.3233/JAD-231363
Alternate JournalJ Alzheimers Dis
PubMed ID38669539
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Source URL: https://www.j-alz.com/content/psychosis-neurodegenerative-dementias-systematic-comparative-review