| Title | Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition. |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Head, D, Bugg, JM, Goate, AM, Fagan, AM, Mintun, MA, Benzinger, T, Holtzman, DM, Morris, JC |
| Journal | Arch Neurol |
| Volume | 69 |
| Issue | 5 |
| Pagination | 636-43 |
| Date Published | 2012 May |
| ISSN | 1538-3687 |
| Keywords | Aged, Aged, 80 and over, Amyloid beta-Peptides, Aniline Compounds, Apolipoprotein E4, Brain, Cognition, Cohort Studies, Exercise, Female, Genetic Association Studies, Genotype, Humans, Male, Middle Aged, Neuropsychological Tests, Peptide Fragments, Positron-Emission Tomography, Regression Analysis, Surveys and Questionnaires, Thiazoles |
| Abstract | OBJECTIVE: APOE ε4 status has been associated with greater cortical amyloid deposition, whereas exercise has been associated with less in cognitively normal adults. The primary objective here was to examine whether physical exercise moderates the association between APOE genotype and amyloid deposition in cognitively normal adults. DESIGN: APOE genotyping data and answers to a questionnaire on physical exercise engagement over the last decade were obtained in conjunction with cerebrospinal fluid (CSF) samples and amyloid imaging with carbon 11-labeled Pittsburgh Compound B ([(11)C]PiB) positron emission tomography. Participants were classified as either low or high exercisers based on exercise guidelines of the American Heart Association. SETTING: Knight Alzheimer's Disease Research Center at Washington University, St Louis, Missouri. PARTICIPANTS: A total of 201 cognitively normal adults (135 of whom were women) aged 45 to 88 years were recruited from the Knight Alzheimer's Disease Research Center. Samples of CSF were collected from 165 participants. Amyloid imaging was performed for 163 participants. RESULTS: APOE ε4 carriers evidenced higher [(11)C]PiB binding (P<.001 and="" lower="" csf="" a="" levels="" than="" did="" noncarriers.="" our="" previous="" findings="" of="" higher="" binding="" in="" more="" sedentary="" individuals="" were="" replicated.="" most="" importantly="" we="" observed="" novel="" interaction="" between="" apoe="" status="" exercise="" engagement="" for="" such="" that="" lifestyle="" was="" significantly="" associated="" with="" carriers="" but="" not="" noncarriers="" all="" remained="" significant="" after="" controlling="" age="" sex="" educational="" level="" body="" mass="" index="" the="" presence="" or="" history="" hypertension="" diabetes="" mellitus="" heart="" problems="" depression="" interval="" assessments.=""> CONCLUSION: Collectively, these results suggest that cognitively normal sedentary APOE ε4-positive individuals may be at augmented risk for cerebral amyloid deposition. |
| DOI | 10.1001/archneurol.2011.845 |
| Alternate Journal | Arch. Neurol. |
| PubMed ID | 22232206 |
| PubMed Central ID | PMC3583203 |
| Grant List | 5T32AG00030 / AG / NIA NIH HHS / United States P01 AG003991 / AG / NIA NIH HHS / United States P01 AG003991-30 / AG / NIA NIH HHS / United States P01 AG026276 / AG / NIA NIH HHS / United States P01 AG026276 / AG / NIA NIH HHS / United States P01 AG026276-07 / AG / NIA NIH HHS / United States P01 AG03991 / AG / NIA NIH HHS / United States P50 AG005681 / AG / NIA NIH HHS / United States P50 AG005681-29 / AG / NIA NIH HHS / United States P50 AG05861 / AG / NIA NIH HHS / United States T32 AG000030 / AG / NIA NIH HHS / United States T32 AG000030-35 / AG / NIA NIH HHS / United States |
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