Journal of Alzheimer's Disease
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Home > The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.

TitleThe diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.
Publication TypeJournal Article
Year of Publication2011
AuthorsAlbert, MS, DeKosky, ST, Dickson, D, Dubois, B, Feldman, HH, Fox, NC, Gamst, A, Holtzman, DM, Jagust, WJ, Petersen, RC, Snyder, PJ, Carrillo, MC, Thies, B, Phelps, CH
JournalAlzheimers Dement
Volume7
Issue3
Pagination270-9
Date Published2011 May
ISSN1552-5279
KeywordsAlzheimer Disease, Biomarkers, Cognition Disorders, Diagnosis, Differential, Diagnostic Imaging, Humans, National Institute on Aging (U.S.), Practice Guidelines as Topic, Societies, Medical, United States
Abstract

The National Institute on Aging and the Alzheimer's Association charged a workgroup with the task of developing criteria for the symptomatic predementia phase of Alzheimer's disease (AD), referred to in this article as mild cognitive impairment due to AD. The workgroup developed the following two sets of criteria: (1) core clinical criteria that could be used by healthcare providers without access to advanced imaging techniques or cerebrospinal fluid analysis, and (2) research criteria that could be used in clinical research settings, including clinical trials. The second set of criteria incorporate the use of biomarkers based on imaging and cerebrospinal fluid measures. The final set of criteria for mild cognitive impairment due to AD has four levels of certainty, depending on the presence and nature of the biomarker findings. Considerable work is needed to validate the criteria that use biomarkers and to standardize biomarker analysis for use in community settings.

DOI10.1016/j.jalz.2011.03.008
Alternate JournalAlzheimers Dement
PubMed ID21514249
PubMed Central IDPMC3312027
Grant ListG0601846 / / Medical Research Council / United Kingdom
P01 AG003949 / AG / NIA NIH HHS / United States
P50 AG005146 / AG / NIA NIH HHS / United States
P50 AG005146-28 / AG / NIA NIH HHS / United States
Top50 Topics: 
Diagnosis
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Source URL: https://www.j-alz.com/content/diagnosis-mild-cognitive-impairment-due-alzheimers-disease-recommendations-national