Title | Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Sperling, RA, Aisen, PS, Beckett, LA, Bennett, DA, Craft, S, Fagan, AM, Iwatsubo, T, Jack, CR, Kaye, J, Montine, TJ, Park, DC, Reiman, EM, Rowe, CC, Siemers, E, Stern, Y, Yaffe, K, Carrillo, MC, Thies, B, Morrison-Bogorad, M, Wagster, MV, Phelps, CH |
Journal | Alzheimers Dement |
Volume | 7 |
Issue | 3 |
Pagination | 280-92 |
Date Published | 2011 May |
ISSN | 1552-5279 |
Keywords | Alzheimer Disease, Biomarkers, Cognition Disorders, Humans, National Institute on Aging (U.S.), Practice Guidelines as Topic, United States |
Abstract | The pathophysiological process of Alzheimer's disease (AD) is thought to begin many years before the diagnosis of AD dementia. This long "preclinical" phase of AD would provide a critical opportunity for therapeutic intervention; however, we need to further elucidate the link between the pathological cascade of AD and the emergence of clinical symptoms. The National Institute on Aging and the Alzheimer's Association convened an international workgroup to review the biomarker, epidemiological, and neuropsychological evidence, and to develop recommendations to determine the factors which best predict the risk of progression from "normal" cognition to mild cognitive impairment and AD dementia. We propose a conceptual framework and operational research criteria, based on the prevailing scientific evidence to date, to test and refine these models with longitudinal clinical research studies. These recommendations are solely intended for research purposes and do not have any clinical implications at this time. It is hoped that these recommendations will provide a common rubric to advance the study of preclinical AD, and ultimately, aid the field in moving toward earlier intervention at a stage of AD when some disease-modifying therapies may be most efficacious. |
DOI | 10.1016/j.jalz.2011.03.003 |
Alternate Journal | Alzheimers Dement |
PubMed ID | 21514248 |
PubMed Central ID | PMC3220946 |
Grant List | K24 AG035007 / AG / NIA NIH HHS / United States K24 AG035007-02 / AG / NIA NIH HHS / United States P01 AG036694 / AG / NIA NIH HHS / United States P01 AG036694-02 / AG / NIA NIH HHS / United States P30 AG008017 / AG / NIA NIH HHS / United States P30 AG019610 / AG / NIA NIH HHS / United States P50 AG005134 / AG / NIA NIH HHS / United States P50 AG005134-29 / AG / NIA NIH HHS / United States R01 AG015819 / AG / NIA NIH HHS / United States |
- Comment
|