Title | Risk of dementia in patients with celiac disease: a population-based cohort study. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Lebwohl, B, Luchsinger, JA, Freedberg, DE, Green, PHR, Ludvigsson, JF |
Journal | J Alzheimers Dis |
Volume | 49 |
Issue | 1 |
Pagination | 179-85 |
Date Published | 2016 |
ISSN | 1875-8908 |
Keywords | Aged, Celiac Disease, Cohort Studies, Databases, Factual, Dementia, Female, Humans, Incidence, Logistic Models, Male, Middle Aged, Proportional Hazards Models, Risk Factors, Sweden |
Abstract | BACKGROUND: Patients with celiac disease (CD) frequently report cognitive symptoms when they are exposed to gluten, and cognitive deficits have been quantified in patients with newly diagnosed CD. OBJECTIVE: To determine whether patients with CD have an increased risk of dementia. METHODS: Using a population-based database of older adults (age ≥50 years) with histologically proven CD (duodenal/jejunal villous atrophy) from all 28 pathology departments in Sweden, we compared the incidence of a subsequent dementia diagnosis to those of age- and gender-matched controls. RESULTS: Among patients with CD (n = 8,846) and controls (n = 43,474), the median age was 63 years and 56% were female. During a median follow-up time of 8.4 years, dementia was diagnosed in 4.3% of CD patients and 4.4% of controls (HR 1.07; 95% CI 0.95-1.20). Although there was an increased risk of dementia in the first year following a diagnosis of CD (HR 1.73; 95% CI 1.15-2.61), this risk was not present in the whole observation period. Among those subjects with a dementia subtype specified, the increased risk was restricted to vascular dementia (HR 1.28; 95% CI 1.00-1.64) and was not present for Alzheimer's dementia (HR 1.12; 95% CI 0.91-1.37). CONCLUSIONS: Patients with CD are not at increased risk for dementia overall, though subgroup analysis suggests that they may be at increased risk for vascular dementia. |
DOI | 10.3233/JAD-150388 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 26444775 |
Grant List | UL1 TR000040 / TR / NCATS NIH HHS / United States |