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Home > Age and its association with low insulin and high amyloid-β peptides in blood.

TitleAge and its association with low insulin and high amyloid-β peptides in blood.
Publication TypeJournal Article
Year of Publication2016
AuthorsLi, H, Zhu, H, Wallack, M, Mwamburi, M, Abdul-Hay, SO, Leissring, MA, Qiu, WQiao
JournalJ Alzheimers Dis
Volume49
Issue1
Pagination129-37
Date Published2016
ISSN1875-8908
KeywordsAge Distribution, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Amyloid beta-Peptides, Apolipoprotein E4, Biomarkers, Cognition Disorders, Cross-Sectional Studies, Female, Humans, Insulin, Islet Amyloid Polypeptide, Linear Models, Male, Middle Aged, Multivariate Analysis, Peptide Fragments
Abstract

Age is the major risk factor for developing Alzheimer's disease (AD), and modifying age-related factors may help to delay the onset of the disease. The goal of this study was to investigate the relationship between age and the metabolic factors related to the risk of developing AD. The concentrations of insulin, amylin, and amyloid-β peptide (Aβ) in plasma were measured. We further measured the activity of serum Aβ degradation by using fluorescein- and biotin-labeled Aβ40. Apolipoprotein E4 allele (ApoE4) and cognitive impairment were characterized. Subjects were divided into three age groups: 60-70, 70-80, and ≥80 years old. We found that the older the subjects, the lower the concentration of insulin (p = 0.001) and the higher the concentration of Aβ1-40 (p = 0.004) in plasma. However, age was not associated with the concentration of another pancreatic peptide, amylin, and only marginally with Aβ1-42. These relationships remained in the absence of diabetes, cardiovascular disease, and stroke, and regardless of the presence of ApoE4 and cognitive impairment. Both age and ApoE4 were inversely associated with, while insulin was positively associated with, the activities of Aβ degradation in serum. Our study suggested that low concentration of insulin and high concentration of Aβ40 are aging factors related to the risk of AD.

DOI10.3233/JAD-150428
Alternate JournalJ. Alzheimers Dis.
PubMed ID26444783
PubMed Central IDPMC4835689
Grant ListK23 AG022476 / AG / NIA NIH HHS / United States
R01 AG049899 / AG / NIA NIH HHS / United States
AG-022476 / AG / NIA NIH HHS / United States
R21 AG045757 / AG / NIA NIH HHS / United States
K24 AG050842 / AG / NIA NIH HHS / United States
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