| Title | Mindfulness in the Maintenance of Cognitive Capacities in Alzheimer's Disease: A Randomized Clinical Trial. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Quintana-Hernández, DJ, Miró-Barrachina, MT, Ibáñez-Fernández, IJ, Del Pino, ASantana-, Quintana-Montesdeoca, MP, de Vera, BRodríguez, Morales-Casanova, D, Pérez-Vieitez, MDel Carmen, Rodríguez-García, J, Bravo-Caraduje, N |
| Journal | J Alzheimers Dis |
| Volume | 50 |
| Issue | 1 |
| Pagination | 217-32 |
| Date Published | 2016 |
| ISSN | 1875-8908 |
| Keywords | Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Analysis of Variance, Cognition Disorders, Double-Blind Method, Female, Humans, Longitudinal Studies, Male, Mental Status Schedule, Mindfulness, Neuropsychological Tests, Treatment Outcome |
| Abstract | BACKGROUND: The Canary Islands longitudinal study on non-pharmacological treatments showed the overall effectiveness of mindfulness in Alzheimer's disease (AD). However, no specific data on the maintenance of cognitive capacities were presented. OBJECTIVE: To determine whether the practice of mindfulness modifies the course of cognitive impairment in AD. METHODS: DESIGN: Longitudinal, non-inferiority and equivalence, randomized clinical trial, repeated-measures design, with three experimental groups and one control group. PARTICIPANTS: Patients with AD who voluntarily attended the Lidia García Foundation (n = 502). Only those who were treated with donepezil and MMSE ≥18 were included (n = 120). INTERVENTION: Over a two-year period, each group carried out three weekly sessions of stimulation based on mindfulness, cognitive stimulation therapy, and progressive muscle relaxation. MEASURES: Cognitive assessment CAMDEX-R (MMSE and CAMCOG). STATISTICAL ANALYSIS: Repeated-measures ANOVA (p RESULTS: The mindfulness group showed significant scores compared with the control and muscle relaxation groups (p CONCLUSION: The practice of mindfulness maintained cognitive function over a period of two years. This longitudinal study suggests that mindfulness can be used as a non-pharmacological treatment to slow cognitive impairment in AD. |
| DOI | 10.3233/JAD-143009 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 26639952 |
