| Title | Cerebrospinal Fluid Anti-Amyloid-β Autoantibodies and Amyloid PET in Cerebral Amyloid Angiopathy-Related Inflammation. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Carmona-Iragui, M, Fernández-Arcos, A, Alcolea, D, Piazza, F, Morenas-Rodriguez, E, Antón-Aguirre, S, Sala, I, Clarimón, J, Dols-Icardo, O, Camacho, V, Sampedro, F, Munuera, J, Nuñez-Marin, F, Lleo, A, Fortea, J, Gómez-Ansón, B, Blesa, R |
| Journal | J Alzheimers Dis |
| Volume | 50 |
| Issue | 1 |
| Pagination | 1-7 |
| Date Published | 2016 |
| ISSN | 1875-8908 |
| Keywords | Aged, Amyloid beta-Peptides, Aniline Compounds, Apolipoproteins E, Autoantibodies, Cerebral Amyloid Angiopathy, Ethylene Glycols, Female, Humans, Magnetic Resonance Imaging, Male, Meningoencephalitis, Peptide Fragments, Positron-Emission Tomography, Statistics, Nonparametric, tau Proteins |
| Abstract | We report a biomarker and genetic evaluation of four patients with cerebral amyloid angiopathy-related inflammation (CAA-ri) treated with corticosteroids. Patients presented with focal symptomatology and cognitive impairment. MRI revealed cortical microbleeds and asymmetrical hyperintense white matter lesions (WML). Cerebrospinal fluid (CSF) biomarker analyses showed increased anti-Aβ autoantibodies, t-Tau, and p-Tau and decreased Aβ40 and Aβ42. After treatment, focal symptomatology disappeared, and WML and anti-Aβ autoantibodies decreased. The APOEɛ4 allele was overrepresented. Florbetapir-PET showed cortical deposition with lower retention in swollen areas. In the case of suspected CAA-ri, both CSF anti-Aβ autoantibodies levels and Florbetapir-PET could provide highly useful data to guide the correct diagnosis. |
| DOI | 10.3233/JAD-150614 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 26639966 |
