Title | Effect of Anserine/Carnosine Supplementation on Verbal Episodic Memory in Elderly People. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Hisatsune, T, Kaneko, J, Kurashige, H, Cao, Y, Satsu, H, Totsuka, M, Katakura, Y, Imabayashi, E, Matsuda, H |
Journal | J Alzheimers Dis |
Volume | 50 |
Issue | 1 |
Pagination | 149-59 |
Date Published | 2016 |
ISSN | 1875-8908 |
Keywords | Adult, Aged, Aging, Anserine, Brain, Carnosine, Cytokines, Dietary Supplements, Double-Blind Method, Female, Gene Expression Regulation, Humans, Image Processing, Computer-Assisted, Male, Memory, Episodic, Middle Aged, Neuropsychological Tests, Oligonucleotide Array Sequence Analysis, Verbal Learning |
Abstract | Our goal in this study was to determine whether or not anserine/carnosine supplementation (ACS) is capable of preserving cognitive function of elderly people. In a double-blind randomized controlled trial, volunteers were randomly assigned to an ACS or placebo group at a 1:1 ratio. The ACS group took 1.0 g of an anserine/carnosine (3:1) formula daily for 3 months. Participants were evaluated by psychological tests before and after the 3-month supplementation period. Thirty-nine healthy elderly volunteers (60-78 years old) completed the follow-up tests. Among the tests, delayed recall verbal memory assessed by the Wechsler Memory Scale-Logical Memory showed significant preservation in the ACS group, compared to the placebo group (p = 0.0128). Blood analysis revealed a decreased secretion of inflammatory cytokines, including CCL-2 and IL-8, in the ACS group. MRI analysis using arterial spin labeling showed a suppression in the age-related decline in brain blood flow in the posterior cingulate cortex area in the ACS group, compared to the placebo group (p = 0.0248). In another randomized controlled trial, delayed recall verbal memory showed significant preservation in the ACS group, compared to the placebo group (p = 0.0202). These results collectively suggest that ACS may preserve verbal episodic memory and brain perfusion in elderly people, although further study is needed. |
DOI | 10.3233/JAD-150767 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 26682691 |
PubMed Central ID | PMC4927867 |