| Title | Cerebrospinal Fluid Alzheimer's Disease Biomarkers in Cerebral Amyloid Angiopathy-Related Inflammation. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Renard, D, Wacongne, A, Ayrignac, X, Charif, M, Fourcade, G, Azakri, S, Le Floch, A, Bouly, S, Marelli, C, Arquizan, C, Hirtz, C, Gabelle, A, Thouvenot, E, Lehmann, S |
| Journal | J Alzheimers Dis |
| Volume | 50 |
| Issue | 3 |
| Pagination | 759-64 |
| Date Published | 2016 |
| ISSN | 1875-8908 |
| Keywords | Aged, Alzheimer Disease, Amyloid beta-Peptides, Biomarkers, Cerebral Amyloid Angiopathy, Female, Humans, Inflammation, Male, Middle Aged, Retrospective Studies, tau Proteins |
| Abstract | BACKGROUND: Decreased cerebrospinal fluid (CSF) amyloid-β 1-40 (Aβ40) and amyloid-β 1-42 (Aβ42) and increased total and phosphorylated tau (t-tau, p-tau) concentrations have been described in cerebral amyloid angiopathy (CAA). OBJECTIVE: Our aim was to analyze these biomarkers in patients with CAA-related inflammation (CAA-I). METHODS: We prospectively recruited nine patients with acute phase CAA-I fulfilling Chung criteria. CSF was analyzed for t-tau, p-tau, Aβ42, and Aβ40. Data were compared to controls (n = 14), patients with Alzheimer's disease (AD, n = 42), CAA (n = 10), and primary angiitis of the central nervous system (PACNS, n = 3). RESULTS: For the CAA-I group, statistically significant differences were: lower Aβ42 (p = 0.00053) compared to the control group; lower t-tau (p = 0.018), p-tau (p CONCLUSION: CSF biomarkers profile similar to that of CAA was observed in CAA-I (with even lower levels of Aβ42 compared to CAA). Based on our findings, high p-tau seems more specific for AD, whereas low Aβ42 differentiates CAA-I from CAA, PACNS, and controls, and low Aβ40 differentiates CAA-I from AD. |
| DOI | 10.3233/JAD-150621 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 26757185 |
