Title | Lower Prevalence of Alzheimer's Disease among Tibetans: Association with Religious and Genetic Factors. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Huang, F, Shang, Y, Luo, Y, Wu, P, Huang, X, Tan, X, Lu, X, Zhen, L, Hu, X |
Journal | J Alzheimers Dis |
Volume | 50 |
Issue | 3 |
Pagination | 659-67 |
Date Published | 2016 |
ISSN | 1875-8908 |
Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Clusterin, Cognition Disorders, Cross-Sectional Studies, Female, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Logistic Models, Male, Middle Aged, Neuropsychological Tests, Polymorphism, Single Nucleotide, Psychiatric Status Rating Scales, Religion, Risk Factors, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Tibet |
Abstract | BACKGROUND: The prevalence of dementia differs among racial groups, the highest prevalence being in Latin America (8.5%) compared to sub-Saharan African regions (2-4%). The most common type of dementia is Alzheimer's disease (AD). OBJECTIVE: To estimate the prevalence of AD in the Qinghai-Tibet plateau and to investigate the related factors. METHODS: This was a cross-sectional, multistage cluster sampling design survey. Data was collected from May 2014 to September 2014 from 4,060 Tibetan aged >60 years. Participants underwent clinical examinations and neuropsychological evaluations. MALDI-TOF was used to test the genotypes of CLU, TFAM, TP53INP1, IGHV1-67, CR1, ApoE, and BIN1. Logistic regression models were used to ascertain the associations with AD. RESULTS: The prevalence of AD among Tibetan individuals aged >60 years was 1.33% (95% CI: 0.98-1.69). The CLU haplotypes AA+GA (odds ratio (OR) = 4.483; 95% CI: 1.069-18.792) of rs2279590 was correlated with AD. The CLU haplotypes GG+GC (OR = 0.184; 95% CI: 0.038-0.888) of rs9331888 and kowtow (OR = 0.203; 95% CI 0.046-0.896) were negatively correlated with AD. CONCLUSION: A low prevalence of AD was found in Tibetans from the Qinghai-Tibet plateau. Multivariate analysis might suggest that regular "mind-body" religious meditative activities may be negatively associated with AD in this population, as well as the CLU genotype at rs9331888. |
DOI | 10.3233/JAD-150697 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 26757186 |