Title | Association of Butyrylcholinesterase-K Allele and Apolipoprotein E ɛ4 Allele with Cognitive Decline in Dementia with Lewy Bodies and Alzheimer's Disease. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Vijayaraghavan, S, Darreh-Shori, T, Rongve, A, Berge, G, Sando, SB, White, LR, Auestad, BH, Witoelar, A, Andreassen, OA, Ulstein, ID, Aarsland, D |
Journal | J Alzheimers Dis |
Volume | 50 |
Issue | 2 |
Pagination | 567-76 |
Date Published | 2016 |
ISSN | 1875-8908 |
Keywords | Aged, Aged, 80 and over, Alleles, Alzheimer Disease, Apolipoprotein E4, Butyrylcholinesterase, Cognition, Disease Progression, Female, Gene Frequency, Genotype, Humans, Lewy Body Disease, Male, Neuropsychological Tests |
Abstract | BACKGROUND: A common polymorphism of the butyrylcholinesterase gene, the K-variant (BCHE-K) is associated with reduced butyrylcholinesterase (BuChE) activity. Insufficient studies exist regarding the frequency and role of BCHE-K in dementias. OBJECTIVE: To determine the association of BCHE-K and APOEɛ4 with diagnosis and rate of cognitive decline in dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) patients. METHODS: Genomic DNA from 368 subjects (108 AD, 174 DLB, and 86 controls) from two routine clinical cohort studies in Norway; DemVest and TrønderBrain, were genotyped for BCHE-K and APOEɛ4. The mild dementia DemVest subjects received annual Mini-Mental State Examination assessments for five years. RESULTS: BCHE-K frequency was lower in DLB (33.9% ; p CONCLUSION: BCHE-K is associated with a reduced risk for AD and DLB whereas APOEɛ4 is associated with more rapid cognitive decline. The greater cognitive decline in individuals with both APOEɛ4 and BCHE-K alleles require prospective confirmation in well-controlled trials. |
DOI | 10.3233/JAD-150750 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 26757188 |