Title | Decreased Inter-Hemispheric Functional Connectivity in Cognitively Intact Elderly APOE ɛ4 Carriers: A Preliminary Study. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Luo, X, Qiu, T, Xu, X, Huang, P, Gu, Q, Shen, Z, Yu, X, Jia, YL, Guan, X, Song, R, Zhang, M |
Corporate Authors | Alzheimer’s Disease Neuroimaging Initiative |
Journal | J Alzheimers Dis |
Volume | 50 |
Issue | 4 |
Pagination | 1137-48 |
Date Published | 2016 |
ISSN | 1875-8908 |
Keywords | Aged, Aging, Apolipoprotein E4, Brain, Brain Mapping, Female, Functional Laterality, Genotyping Techniques, Heterozygote, Humans, Magnetic Resonance Imaging, Male, Memory, Neuropsychological Tests, Rest |
Abstract | The apolipoprotein E (APOE) ɛ4 allele is the best-known genetic risk factor for developing sporadic Alzheimer's disease (AD). According to neuroimaging studies, the APOE ɛ4 allele is associated with localized altered brain function. However, in long-range circuitry, APOE ɛ4 allele-related alterations in functional communication between hemispheres have rarely been directly investigated. We examined the alteration of resting-state functional connectivity (RSFC) between inter-hemispheric homotopic regions in cognitively intact, elderly APOE ɛ4 carriers. The voxel-mirrored homotopic connectivity method was used to assess the inter-hemispheric RSFC. The current study included 13 cognitively intact, elderly APOE ɛ4 carriers (with at least one copy of APOE ɛ4 allele) and 22 well-matched ɛ3 homozygotes. Comparisons between the two groups were conducted, and subsequently, the correlation between the differential inter-hemispheric RSFC and cognitive ability was analyzed. Compared with ɛ3 homozygotes, APOE ɛ4 carriers showed decreased inter-hemispheric RSFC in the bilateral medial temporal lobe (MTL) and orbital frontal cortex (OFC). Moreover, in APOE ɛ4 carriers, the inter-hemispheric RSFC of the MTL correlated with the Wechsler Memory Scale-Logical Memory (WMS-LM) (immediate and delayed performance, r = 0.64, p |
DOI | 10.3233/JAD-150989 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 26836191 |
Grant List | U01AG024904 / AG / NIA NIH HHS / United States / / Canadian Institutes of Health Research / Canada |