| Title | The Disconnection Hypothesis in Alzheimer's Disease Studied Through Multimodal Magnetic Resonance Imaging: Structural, Perfusion, and Diffusion Tensor Imaging. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Lacalle-Aurioles, M, Navas-Sánchez, FJavier, Alemán-Gómez, Y, Olazarán, J, Guzmán-De-Villoria, JAdán, Cruz-Orduña, I, Mateos-Pérez, JMaría, Desco, M |
| Journal | J Alzheimers Dis |
| Volume | 50 |
| Issue | 4 |
| Pagination | 1051-64 |
| Date Published | 2016 |
| ISSN | 1875-8908 |
| Keywords | Aged, Alzheimer Disease, Brain, Brain Mapping, Cerebral Angiography, Cerebrovascular Circulation, Cognitive Dysfunction, Diffusion Tensor Imaging, Female, Functional Laterality, Humans, Magnetic Resonance Imaging, Male, Mental Status Schedule, Models, Neurological, Multimodal Imaging, Organ Size, Prospective Studies |
| Abstract | According to the so-called disconnection hypothesis, the loss of synaptic inputs from the medial temporal lobes (MTL) in Alzheimer's disease (AD) may lead to reduced activity of target neurons in cortical areas and, consequently, to decreased cerebral blood flow (CBF) in those areas. The aim of this study was to assess whether hypoperfusion in parietotemporal and frontal cortices of patients with mild cognitive impairment who converted to AD (MCI-c) and patients with mild AD is associated with atrophy in the MTL and/or microstructural changes in the white matter (WM) tracts connecting these areas. We assessed these relationships by investigating correlations between CBF in hypoperfused areas, mean cortical thickness in atrophied regions of the MTL, and fractional anisotropy (FA) in WM tracts. In the MCI-c group, a strong correlation was observed between CBF of the superior parietal gyri and FA in the parahippocampal tracts (left: r = 0.90, p |
| DOI | 10.3233/JAD-150288 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 26890735 |
