Title | Self-Reported Traumatic Brain Injury and Mild Cognitive Impairment: Increased Risk and Earlier Age of Diagnosis. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | LoBue, C, Denney, D, Hynan, LS, Rossetti, HC, Lacritz, LH, Hart, J, Womack, KB, Woon, FL, C Cullum, M |
Journal | J Alzheimers Dis |
Volume | 51 |
Issue | 3 |
Pagination | 727-36 |
Date Published | 2016 |
ISSN | 1875-8908 |
Keywords | Age of Onset, Aged, Apolipoproteins E, Brain Injuries, Traumatic, Cognitive Dysfunction, Cohort Studies, Databases, Factual, Depression, Educational Status, Female, Humans, Logistic Models, Male, Risk Factors, Self Report, United States |
Abstract | This study examined whether history of traumatic brain injury (TBI) is associated with increased risk and earlier onset of mild cognitive impairment (MCI). Subjects with MCI (n = 3,187) and normal cognition (n = 3,244) were obtained from the National Alzheimer's Coordinating Center database. TBI was categorized based on lifetime reported TBI with loss of consciousness (LOC) without chronic deficit. Logistic regression was used to examine TBI history as a predictor of MCI, adjusted for demographics, apolipoprotein E-ɛ4 (ApoE4), a composite vascular risk score, and history of psychiatric factors. ANCOVA was used to examine whether age at MCI diagnosis and estimated age of onset differed between those with (TBI+) and without (TBI-) a history of TBI. TBI history was a significant predictor (p |
DOI | 10.3233/JAD-150895 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 26890760 |
PubMed Central ID | PMC4853649 |
Grant List | P30 AG013854 / AG / NIA NIH HHS / United States P30AG028383 / AG / NIA NIH HHS / United States P30 AG010124 / AG / NIA NIH HHS / United States P50 AG023501 / AG / NIA NIH HHS / United States P50 AG005142 / AG / NIA NIH HHS / United States P50 AG005131 / AG / NIA NIH HHS / United States P30 AG010133 / AG / NIA NIH HHS / United States P50 AG016574 / AG / NIA NIH HHS / United States P50 AG005146 / AG / NIA NIH HHS / United States U01 AG032984 / AG / NIA NIH HHS / United States P50AG023501 / AG / NIA NIH HHS / United States P30 AG035982 / AG / NIA NIH HHS / United States P50 AG008702 / AG / NIA NIH HHS / United States U01 AG016976 / AG / NIA NIH HHS / United States P30 AG008051 / AG / NIA NIH HHS / United States P50 AG005681 / AG / NIA NIH HHS / United States P30 AG013846 / AG / NIA NIH HHS / United States P50 AG005136 / AG / NIA NIH HHS / United States P30 AG012300 / AG / NIA NIH HHS / United States P50AG016574 / AG / NIA NIH HHS / United States P50 AG016573 / AG / NIA NIH HHS / United States P50 AG016570 / AG / NIA NIH HHS / United States P50 AG005134 / AG / NIA NIH HHS / United States P30 AG008017 / AG / NIA NIH HHS / United States P30 AG010161 / AG / NIA NIH HHS / United States P50 AG025688 / AG / NIA NIH HHS / United States P50 AG005133 / AG / NIA NIH HHS / United States P50 AG005138 / AG / NIA NIH HHS / United States P30 AG010129 / AG / NIA NIH HHS / United States P30 AG019610 / AG / NIA NIH HHS / United States P30 AG028383 / AG / NIA NIH HHS / United States P50 AG033514 / AG / NIA NIH HHS / United States |