| Title | Associations between Serum Omega-3 Fatty Acid Levels and Cognitive Functions among Community-Dwelling Octogenarians in Okinawa, Japan: The KOCOA Study. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Nishihira, J, Tokashiki, T, Higashiuesato, Y, Willcox, DCraig, Mattek, N, Shinto, L, Ohya, Y, Dodge, HH |
| Journal | J Alzheimers Dis |
| Volume | 51 |
| Issue | 3 |
| Pagination | 857-66 |
| Date Published | 2016 |
| ISSN | 1875-8908 |
| Keywords | Age Factors, Aged, 80 and over, Arachidonic Acid, Blood Chemical Analysis, Cognition, Cross-Sectional Studies, Educational Status, Fatty Acids, Omega-3, Female, Humans, Japan, Logistic Models, Male, Mental Status Schedule, Obesity, Prospective Studies, Sex Factors |
| Abstract | BACKGROUND: Epidemiological studies have found frequent consumption of fatty fish is protective against cognitive decline. However, the association between circulating omega-3 polyunsaturated fatty acid (PUFA) levels and cognitive functions among the oldest old is not well known. OBJECTIVE: To examine the association between serum PUFA levels and cognitive function among community-dwelling, non-demented elderly aged over 80 years old. METHODS: The data came from the Keys to Optimal Cognitive Aging (KOCOA) study; an ongoing cohort of relatively healthy volunteers aged over 80 years old, living in Okinawa, Japan. One hundred eighty five participants (mean age 84.1±3.4 years) assessed in 2011 who were free from frank dementia (defined as Clinical Dementia Rating RESULTS: Serum DHA levels decreased with increasing age (p = 0.04). Higher global cognitive function was associated with higher levels of serum EPA (p = 0.03) and DHA + EPA (p = 0.03) after controlling for confounders. CONCLUSIONS: Higher serum EPA and DHA + EPA levels were independently associated with better scores on global cognitive function among the oldest old, free from dementia. Longitudinal follow-up studies are warranted. |
| DOI | 10.3233/JAD-150910 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 26890763 |
| PubMed Central ID | PMC4816662 |
| Grant List | K01 AG023014 / AG / NIA NIH HHS / United States P30 AG008017 / AG / NIA NIH HHS / United States K01AG023014 / AG / NIA NIH HHS / United States |
