Title | Association of Serum Vitamin D with the Risk of Incident Dementia and Subclinical Indices of Brain Aging: The Framingham Heart Study. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Karakis, I, Pase, MP, Beiser, A, Booth, SL, Jacques, PF, Rogers, G, DeCarli, C, Vasan, RS, Wang, TJ, Himali, JJ, Annweiler, C, Seshadri, S |
Journal | J Alzheimers Dis |
Volume | 51 |
Issue | 2 |
Pagination | 451-61 |
Date Published | 2016 |
ISSN | 1875-8908 |
Keywords | Adult, Aging, Brain, Cohort Studies, Dementia, Female, Humans, Incidence, Magnetic Resonance Imaging, Male, Middle Aged, Multivariate Analysis, Neuropsychological Tests, Regression Analysis, Risk, Sensitivity and Specificity, Vitamin D |
Abstract | BACKGROUND: Identifying nutrition- and lifestyle-based risk factors for cognitive impairment and dementia may aid future primary prevention efforts. OBJECTIVE: We aimed to examine the association of serum vitamin D levels with incident all-cause dementia, clinically characterized Alzheimer's disease (AD), MRI markers of brain aging, and neuropsychological function. METHODS: Framingham Heart Study participants had baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations measured between 1986 and 2001. Vitamin D status was considered both as a continuous variable and dichotomized as deficient ( RESULTS: In adjusted models, participants with vitamin D deficiency (n = 104, 8% of the cognitive sample) displayed poorer performance on Trail Making B-A (β= -0.03 to -0.05±0.02) and the Hooper Visual Organization Test (β= -0.09 to -0.12±0.05), indicating poorer executive function, processing speed, and visuo-perceptual skills. These associations remained when vitamin D was examined as a continuous variable or dichotomized at the cohort specific 20th percentile. Vitamin D deficiency was also associated with lower hippocampal volumes (β= -0.01±0.01) but not total brain volume, white matter hyperintensities, or silent brain infarcts. No association was found between vitamin D deficiency and incident all-cause dementia or clinically characterized AD. CONCLUSIONS: In this large community-based sample, low 25(OH)D concentrations were associated with smaller hippocampal volume and poorer neuropsychological function. |
DOI | 10.3233/JAD-150991 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 26890771 |
PubMed Central ID | PMC4911705 |
Grant List | N01-HC-25195 / HC / NHLBI NIH HHS / United States R01 NS017950 / NS / NINDS NIH HHS / United States R01 AG016495 / AG / NIA NIH HHS / United States R01 AG042292 / AG / NIA NIH HHS / United States R01 NS17950 / NS / NINDS NIH HHS / United States N01 HC025195 / HC / NHLBI NIH HHS / United States AG033193 / AG / NIA NIH HHS / United States R01 AG008122 / AG / NIA NIH HHS / United States R01 AG033193 / AG / NIA NIH HHS / United States AG031287 / AG / NIA NIH HHS / United States N01HC25195 / HL / NHLBI NIH HHS / United States P30 AG010129 / AG / NIA NIH HHS / United States AG008122 / AG / NIA NIH HHS / United States R01 AG031287 / AG / NIA NIH HHS / United States |