Title | The Vanderbilt Memory & Aging Project: Study Design and Baseline Cohort Overview. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Jefferson, AL, Gifford, KA, Mae Y Acosta, L, Bell, SP, Donahue, MJ, L Davis, T, Gottlieb, JA, Gupta, DK, Hohman, TJ, Lane, EM, Libon, DJ, Mendes, LA, Niswender, K, Pechman, KR, Rane, S, Ruberg, FL, Su, YRu, Zetterberg, H, Liu, D |
Journal | J Alzheimers Dis |
Volume | 52 |
Issue | 2 |
Pagination | 539-59 |
Date Published | 2016 03 08 |
ISSN | 1875-8908 |
Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Biomarkers, Blood Pressure Monitoring, Ambulatory, Brain, Case-Control Studies, Cerebral Angiography, Cognitive Dysfunction, Echocardiography, Epidemiologic Research Design, Female, Follow-Up Studies, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Research Design |
Abstract | BACKGROUND: Vascular health factors frequently co-occur with Alzheimer's disease (AD). A better understanding of how systemic vascular and cerebrovascular health intersects with clinical and pathological AD may inform prevention and treatment opportunities. OBJECTIVE: To establish the Vanderbilt Memory & Aging Project, a case-control longitudinal study investigating vascular health and brain aging, and describe baseline methodology and participant characteristics. METHODS: From September 2012 to November 2014, 335 participants age 60- 92 were enrolled, including 168 individuals with mild cognitive impairment (MCI, 73±8 years, 41% female) and 167 age-, sex-, and race-matched cognitively normal controls (NC, 72±7 years, 41% female). At baseline, participants completed a physical and frailty examination, fasting blood draw, neuropsychological assessment, echocardiogram, cardiac MRI, and brain MRI. A subset underwent 24-hour ambulatory blood pressure monitoring and lumbar puncture for cerebrospinal fluid (CSF) collection. RESULTS: As designed, participant groups were comparable for age (p = 0.31), sex (p = 0.95), and race (p = 0.65). MCI participants had greater Framingham Stroke Risk Profile scores (p = 0.008), systolic blood pressure values (p = 0.008), and history of left ventricular hypertrophy (p = 0.04) than NC participants. As expected, MCI participants performed worse on all neuropsychological measures (p-values CONCLUSION: Diverse sources of baseline and longitudinal data will provide rich opportunities to investigate pathways linking vascular and cerebrovascular health, clinical and pathological AD, and neurodegeneration contributing to novel strategies to delay or prevent cognitive decline. |
DOI | 10.3233/JAD-150914 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 26967211 |
PubMed Central ID | PMC4866875 |
Grant List | UL1 TR000445 / TR / NCATS NIH HHS / United States K23 AG048347 / AG / NIA NIH HHS / United States R01 HL111516 / HL / NHLBI NIH HHS / United States K12 HL109019 / HL / NHLBI NIH HHS / United States K23 AG030962 / AG / NIA NIH HHS / United States K23 AG045966 / AG / NIA NIH HHS / United States K12 HD043483 / HD / NICHD NIH HHS / United States K24 AG046373 / AG / NIA NIH HHS / United States F32 AG046093 / AG / NIA NIH HHS / United States R01 AG034962 / AG / NIA NIH HHS / United States |