| Title | Association of Frontotemporal Dementia GWAS Loci with Late-Onset Alzheimer's Disease in a Northern Han Chinese Population. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Tan, C-C, Wan, Y, Tan, M-S, Zhang, W, Wang, Z-X, Sun, F-R, Miao, D, Tan, L, Yu, J-T |
| Journal | J Alzheimers Dis |
| Volume | 52 |
| Issue | 1 |
| Pagination | 43-50 |
| Date Published | 2016 02 26 |
| ISSN | 1875-8908 |
| Keywords | Age of Onset, Aged, Alzheimer Disease, Apolipoprotein E4, Asian Continental Ancestry Group, Case-Control Studies, China, Female, Frontotemporal Dementia, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Genotyping Techniques, Humans, Linkage Disequilibrium, Male, Mental Status Schedule, Polymorphism, Single Nucleotide |
| Abstract | BACKGROUND: Both Alzheimer's disease (AD) and frontotemporal dementia (FTD) are a class of neurodegenerative diseases. Strong similarities in cerebrospinal fluid biomarker, imaging markers, and disease progression profiles suggest that some or most of the pathophysiology is shared between AD and FTD. A recent large genome-wide association study reported several single nucleotide polymorphisms (SNPs) at the RAB38, RAB38/CTSC, HLA-DRA/HLA-DRB5, and BTNL2 in association with FTD. OBJECTIVE: To explore whether these SNPs are associated with AD risk. METHODS: We conducted a case-control study to investigate the association of FTD-associated loci in 2338 Han Chinese subjects. RESULTS: We observed significant differences in genotype distributions of rs302668 (pc = 0.025), rs9268877 (pc = 0.025), rs9268856 (p CONCLUSION: The SNPs rs302668 in RAB38, rs9268877 and rs9268856 polymorphism in HLA-DRA/HLA-DRB5, and rs1980493 polymorphism in BTNL2 might play a role in the susceptibility to late-onset AD in the Han Chinese population. |
| DOI | 10.3233/JAD-151073 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 26967218 |
