| Title | Maintenance of Cognitive Performance and Mood for Individuals with Alzheimer's Disease Following Consumption of a Nutraceutical Formulation: A One-Year, Open-Label Study. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Remington, R, Bechtel, C, Larsen, D, Samar, A, Page, R, Morrell, C, Shea, TB |
| Journal | J Alzheimers Dis |
| Volume | 51 |
| Issue | 4 |
| Pagination | 991-5 |
| Date Published | 2016 |
| ISSN | 1875-8908 |
| Keywords | Aged, Aged, 80 and over, alpha-Tocopherol, Alzheimer Disease, Cognition Disorders, Dietary Supplements, Disease Progression, Female, Folic Acid, Follow-Up Studies, Humans, Male, Mood Disorders, Neuropsychological Tests, Psychiatric Status Rating Scales, Time Factors, Vitamin B 12 |
| Abstract | Nutritional interventions have shown varied efficacy on cognitive performance during Alzheimer's disease (AD). Twenty-four individuals diagnosed with AD received a nutraceutical formulation (NF: folate, alpha-tocopherol, B12, S-adenosyl methioinine, N-acetyl cysteine, acetyl-L-carnitine) under open-label conditions (ClinicalTrials.gov NCT01320527). Primary outcome was cognitive performance. Secondary outcomes were behavioral and psychological symptoms of dementia (BPSD) and activities of daily living. Participants maintained their baseline cognitive performance and BPSD over 12 months. These findings are consistent with improvement in cognitive performance and BPSD in prior placebo-controlled studies with NF, and contrast with the routine decline for participants receiving placebo. |
| DOI | 10.3233/JAD-151098 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 26967219 |
