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Home > Incidence and Duration of Cumulative Bisphosphonate Use among Community-Dwelling Persons with or without Alzheimer's Disease.

TitleIncidence and Duration of Cumulative Bisphosphonate Use among Community-Dwelling Persons with or without Alzheimer's Disease.
Publication TypeJournal Article
Year of Publication2016
AuthorsTiihonen, M, Taipale, H, Tanskanen, A, Tiihonen, J, Hartikainen, S
JournalJ Alzheimers Dis
Volume52
Issue1
Pagination127-32
Date Published2016
ISSN1875-8908
Abstract

We studied the incidence and duration of cumulative bisphosphonate use among older Finnish women and men with or without Alzheimer's disease (AD). The MEDALZ-2005 cohort is a nationwide sample of all persons with clinically diagnosed AD on 31 December 2005 and their age-, gender-, and region of residence-matched control persons without AD. Information on bisphosphonate use by persons with an AD diagnosis and their controls without AD during 2002-2009 was obtained from the prescription register database containing reimbursed medications. A total of 6,041 (11.8%) persons used bisphosphonates during the 8-year follow-up. Bisphosphonates were more commonly used among persons without AD (n = 3121, 12.3%) than among persons with AD (n = 2,920, 11.2%) (p = 0.001). The median duration of bisphosphonate use was 743 days (IQR). Among persons with AD, the median duration of use was 777 days (IQR) and among persons without AD, 701 days (IQR) (p = 0.011). People without AD more often used bisphosphonate combination preparations including vitamin D than did people with AD (p 

DOI10.3233/JAD-151181
Alternate JournalJ. Alzheimers Dis.
PubMed ID26967224
PubMed Central IDPMC4927880
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Source URL: https://www.j-alz.com/content/incidence-and-duration-cumulative-bisphosphonate-use-among-community-dwelling-persons-or