Title | Formal Psychiatric Disorders are not Overrepresented in Behavioral Variant Frontotemporal Dementia. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Gossink, FT, Dols, A, Krudop, WA, Sikkes, SA, Kerssens, CJ, Prins, ND, Scheltens, P, Stek, ML, Pijnenburg, YAL |
Journal | J Alzheimers Dis |
Volume | 51 |
Issue | 4 |
Pagination | 1249-56 |
Date Published | 2016 |
ISSN | 1875-8908 |
Keywords | Aged, Cohort Studies, Diagnostic and Statistical Manual of Mental Disorders, Female, Frontotemporal Dementia, Humans, Male, Mental Disorders, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales |
Abstract | While psychiatric misdiagnosis is well-known in behavioral variant frontotemporal dementia (bvFTD), a systematic evaluation of standardized criteria for psychiatric disorders in bvFTD is still missing. Our aim was to define frequency and character of DSM-IV psychiatric disorders among patients with probable and definite bvFTD compared to possible bvFTD, other neurodegenerative diseases, and psychiatric diagnoses, using MINI-International Neuropsychiatric Interview. We additionally compared psychiatric prodromes between these groups. Subjects were participants of the late-onset frontal lobe (LOF) study, a longitudinal multicenter study. In each patient, after baseline diagnostic procedure, a neurologist and geriatric psychiatrist made a joint clinical diagnosis. Independently, a structured diagnostic interview according to DSM-IV and ICD-10 criteria (MINI-Plus) was performed by a trained professional blinded to clinical diagnosis. Out of 91 patients, 23 with probable and definite bvFTD, 3 with possible bvFTD, 25 with a non bvFTD neurodegenerative disease, and 40 with a clinical psychiatric diagnosis were included. Overall frequency of formal current and past psychiatric disorders in probable and definite bvFTD (21.7% current, 8.7% past) did not differ from other neurodegenerative diseases (12.0% current, 16.0% past) or possible bvFTD (66.7% current, 66.7% past), but was less than in patients with a clinical psychiatric diagnosis (57.5% current, 62.5% past; p |
DOI | 10.3233/JAD-151198 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 26967225 |