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TitleAquaporin-4 and Alzheimer's Disease.
Publication TypeJournal Article
Year of Publication2016
AuthorsYang, C, Huang, X, Huang, X, Mai, H, Li, J, Jiang, T, Wang, X, Lü, T
JournalJ Alzheimers Dis
Volume52
Issue2
Pagination391-402
Date Published2016 Mar 25
ISSN1875-8908
Abstract

Alzheimer's disease (AD) is the most common form of dementia. Although the pathogenesis of AD remains unclear, AD is thought to result from an imbalance in the production and clearance of amyloid-β protein (Aβ). Aquaporin-4 (AQP4) is the major aquaporin in the mammalian brain, is mostly expressed on astrocytic endfeet, and functions as a water transporter. However, the distribution and expression of AQP4 are altered in both AD clinical populations and animal models. Recent studies have revealed that AQP4 is important to the clearance of Aβ in brain via lymphatic clearance, transcytotic delivery, and glial degradation, as well as to the synaptic function. Thus, AQP4 likely plays an important role in the pathogenesis of AD. Further studies would provide new targets for prevention, ultimately leading to improved treatment options for AD.

DOI10.3233/JAD-150949
Alternate JournalJ. Alzheimers Dis.
PubMed ID27031475
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Source URL: https://www.j-alz.com/content/aquaporin-4-and-alzheimers-disease