Title | Intracerebroventricular Infusion of Angiotensin-(1-7) Ameliorates Cognitive Impairment and Memory Dysfunction in a Mouse Model of Alzheimer's Disease. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Uekawa, K, Hasegawa, Y, Senju, S, Nakagata, N, Ma, M, Nakagawa, T, Koibuchi, N, Kim-Mitsuyama, S |
Journal | J Alzheimers Dis |
Volume | 53 |
Issue | 1 |
Pagination | 127-33 |
Date Published | 2016 Apr 23 |
ISSN | 1875-8908 |
Abstract | This work was performed to test our hypothesis that angiotensin-(1-7) can ameliorate cognitive impairment and cerebrovascular reactivity in 5XFAD mice, a useful model of Alzheimer's disease. 5XFAD mice received intracerebroventricular infusion of (1) vehicle, (2) angiotensin-(1-7), or (3) angiotensin-(1-7)+A779, a specific Mas receptor antagonist, for 4 weeks. Angiotensin-(1-7), through Mas receptor, significantly ameliorated cognitive impairment in 5XFAD mice. As estimated by acetazolamide-induced increase in cerebral blood flow, angiotensin-(1-7), through Mas receptor, enhanced cerebrovascular reactivity in 5XFAD mice. In conclusion, angiotensin-(1-7)/Mas receptor axis improves cognitive function and cerebrovascular function in a mouse model of Alzheimer's disease. |
DOI | 10.3233/JAD-150642 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 27128367 |