| Title | Association of Platelet Serotonin Levels in Alzheimer's Disease with Clinical and Cerebrospinal Fluid Markers. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Tajeddinn, W, Fereshtehnejad, S-M, Ahmed, MSeed, Yoshitake, T, Kehr, J, Shahnaz, T, Milovanovic, M, Behbahani, H, Höglund, K, Winblad, B, Cedazo-Minguez, A, Jelic, V, Järemo, P, Aarsland, D |
| Journal | J Alzheimers Dis |
| Volume | 53 |
| Issue | 2 |
| Pagination | 621-30 |
| Date Published | 2016 May 04 |
| ISSN | 1875-8908 |
| Abstract | INTRODUCTION: Serotonin (5-HT) is involved in the pathology of Alzheimer's disease (AD). OBJECTIVE: We aimed to measure 5-HT level in platelets in AD and explore its association with cerebrospinal fluid (CSF), AD biomarkers (amyloid-β 1-42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau)), and clinical symptoms. METHODS: 15 patients with AD and 20 patients with subjective cognitive impairment (SCI) were included. 5-HT metabolites were measured, in a specific fraction, using high performance liquid chromatography with electrochemical detection (HPLC-ECD). RESULTS: Significantly lower 5-HT concentrations were observed in AD patients compared to SCI patients both after normalization against total protein (p = 0.008) or platelet count (p = 0.019). SCI patients with lower 5-HT level have higher AD CSF biomarkers, total tau (p = 0.026) and tau/Aβ42 ratio (p = 0.001), compared to those with high 5-HT levels. CONCLUSION: AD patients have reduced platelet 5-HT levels. In SCI, lower 5-HT content was associated with a higher AD-CSF biomarker burden. |
| DOI | 10.3233/JAD-160022 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 27163811 |
