Title | Association of Coffee Consumption with MRI Markers and Cognitive Function: A Population-Based Study. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Araújo, LFortunato, Mirza, SSaeed, Bos, D, Niessen, WJ, Barreto, SMaria, van der Lugt, A, Vernooij, MW, Hofman, A, Tiemeier, H, M Ikram, A |
Journal | J Alzheimers Dis |
Volume | 53 |
Issue | 2 |
Pagination | 451-61 |
Date Published | 2016 May 03 |
ISSN | 1875-8908 |
Abstract | BACKGROUND: Coffee is one of the most widely consumed beverages worldwide and has been of considerable interest in research on cognition and dementia. OBJECTIVE: To investigate the effect of coffee on preclinical brain MRI markers of dementia and cognitive performance. METHODS: In 2,914 participants from the population-based Rotterdam Study (mean age: 59.3±7.2 years, 55% females), we assessed coffee consumption, performed brain MRI, and assessed cognition at baseline. To study cognitive change, cognitive assessment was repeated after 5 years of follow-up. Coffee consumption was analyzed continuously (per cup increase) and in categories (0-1, >1-3, >3 cups/day). Using logistic and linear regression, associations of coffee consumption with lacunar infarcts and brain tissue volumes on MRI, and cognitive performance (cross-sectional and longitudinal) were investigated, adjusting for relevant confounders. RESULTS: We found that higher coffee consumption was associated with a lower prevalence of lacunar infarcts [odds ratio per cup increase: 0.88 (95% CI:0.79;0.98)], and smaller hippocampal volume [difference: -0.01 (95% CI:-0.02;0.00)]. Also, we found that the highest category of coffee consumption was associated with better performance on the Letter Digit Substitution Task [difference: 1.13(95% CI:0.39;1.88)], Word Fluency test [0.74(95% CI:0.04,1.45)], Stroop interference task [1.82(95% CI:0.23;3.41)], and worse performance on the 15-Word Learning test delayed recall [-0.38(95% CI:-0.74;-0.02)]. These associations were not found when cognition was analyzed longitudinally. CONCLUSION: We found complex associations between coffee consumption, brain structure, and cognition. Higher coffee consumption was cross-sectionally associated with a lower occurrence of lacunar infarcts and better executive function, but also with smaller hippocampal volume and worse memory function. |
DOI | 10.3233/JAD-160116 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 27163820 |