Journal of Alzheimer's Disease
Published on Journal of Alzheimer's Disease (https://www.j-alz.com)

Home > Early Cognitive Deficits in Type 2 Diabetes: A Population-Based Study.

TitleEarly Cognitive Deficits in Type 2 Diabetes: A Population-Based Study.
Publication TypeJournal Article
Year of Publication2016
AuthorsMarseglia, A, Fratiglioni, L, Laukka, EJ, Santoni, G, Pedersen, NL, Bäckman, L, Xu, W
JournalJ Alzheimers Dis
Volume53
Issue3
Pagination1069-78
Date Published2016 Jun 15
ISSN1875-8908
Abstract

Evidence links type 2 diabetes to dementia risk. However, our knowledge on the initial cognitive deficits in diabetic individuals and the factors that might promote such deficits is still limited. This study aimed to identify the cognitive domains initially impaired by diabetes and the factors that play a role in this first stage. Within the population-based Swedish National Study on Aging and Care-Kungsholmen, 2305 cognitively intact participants aged ≥60 y were identified. Attention/working memory, perceptual speed, category fluency, letter fluency, semantic memory, and episodic memory were assessed. Diabetes (controlled and uncontrolled) and prediabetes were ascertained by clinicians, who also collected information on vascular disorders (hypertension, heart diseases, and stroke) and vascular risk factors (VRFs, including smoking and overweight/obesity). Data were analyzed with linear regression models. Overall, 196 participants (8.5%) had diabetes, of which 144 (73.5%) had elevated glycaemia (uncontrolled diabetes); 571 (24.8%) persons had prediabetes. In addition, diabetes, mainly uncontrolled, was related to lower performance in perceptual speed (β - 1.10 [95% CI - 1.98, - 0.23]), category fluency (β - 1.27 [95% CI - 2.52, - 0.03]), and digit span forward (β - 0.35 [95% CI - 0.54, - 0.17]). Critically, these associations were present only among APOEɛ4 non-carriers. The associations of diabetes with perceptual speed and category fluency were present only among participants with VRFs or vascular disorders. Diabetes, especially uncontrolled diabetes, is associated with poorer performance in perceptual speed, category fluency, and attention/primary memory. VRFs, vascular disorders, and APOE status play a role in these associations.

DOI10.3233/JAD-160266
Alternate JournalJ. Alzheimers Dis.
PubMed ID27314527
PubMed Central IDPMC4981902
E-mail Icon
Comment Icon
  • Comment
|
  • 1 comment
Bookmark Icon Bookmark Recommend Icon Recommend Follow Icon Follow
  • Comment
| Bookmark | Recommend | Follow

Source URL: https://www.j-alz.com/content/early-cognitive-deficits-type-2-diabetes-population-based-study