Title | Motoric Cognitive Risk Syndrome and Falls Risk: A Multi-Center Study. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Callisaya, ML, Ayers, E, Barzilai, N, Ferrucci, L, Guralnik, JM, Lipton, RB, Otahal, P, Srikanth, VK, Verghese, J |
Journal | J Alzheimers Dis |
Volume | 53 |
Issue | 3 |
Pagination | 1043-52 |
Date Published | 2016 Jun 18 |
ISSN | 1875-8908 |
Abstract | BACKGROUND: The Motoric Cognitive Risk Syndrome (MCR) is characterized by slow gait speed and cognitive complaints. OBJECTIVES: The objective of this study was to determine if the presence of MCR increases the risk of falls in older people. METHODS: Individual participant data (n = 6,204) from five longitudinal studies from three countries were used for this analysis. MCR diagnosis was defined as both the presence of objectively measured slow gait speed and subjective cognitive complaints in those without dementia or mobility disability. Falls were prospectively ascertained using phone calls or questionnaires. Log binomial regression was performed to determine if MCR increased the risk of falls separately in each cohort. Random effects meta-analysis was used to pool results from all cohorts. RESULTS: The mean age of participants was 74.9 (SD 6.8) years and 44% (n = 2728) were male. Overall 33.9% (n = 2104) reported a fall over follow-up. Pooled relative risk of MCR with any falls was RR 1.44 95% CI 1.16, 1.79. The components of MCR, slow gait (RR 1.30 95% CI 1.14, 1.47) and cognitive complaint (RR 1.25, 95% CI 1.07, 1.46) were also associated with an increased risk of any falls. In sub-analyses MCR was associated with any fall independent of previous falls (RR 1.29 95% CI 1.09, 1.53) and with multiple falls (RR 1.77, 95% CI 1.25, 2.51). CONCLUSION: MCR is associated with an increased risk of falls. The increase in risk was higher than for its individual components. The simplicity of the MCR makes it an attractive falls risk screening tool for the clinic. |
DOI | 10.3233/JAD-160230 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 27340851 |
PubMed Central ID | PMC5139681 |
Grant List | R01 AG042188 / AG / NIA NIH HHS / United States R00 AG037574 / AG / NIA NIH HHS / United States R01 AG046949 / AG / NIA NIH HHS / United States U01 AG009740 / AG / NIA NIH HHS / United States KL2 TR000088 / TR / NCATS NIH HHS / United States ZIA AG001050 / AG / NIA NIH HHS / United States P01 AG034906 / AG / NIA NIH HHS / United States R37 AG018381 / AG / NIA NIH HHS / United States R01 AG044829 / AG / NIA NIH HHS / United States Z01 AG000015-49 / / Intramural NIH HHS / United States P30 AG038072 / AG / NIA NIH HHS / United States P01 AG003949 / AG / NIA NIH HHS / United States |