Title | FDG-PET and Neuropsychiatric Symptoms among Cognitively Normal Elderly Persons: The Mayo Clinic Study of Aging. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Krell-Roesch, J, Ruider, H, Lowe, VJ, Stokin, GB, Pink, A, Roberts, RO, Mielke, MM, Knopman, DS, Christianson, TJ, Machulda, MM, Jack, CR, Petersen, RC, Geda, YE |
Journal | J Alzheimers Dis |
Volume | 53 |
Issue | 4 |
Pagination | 1609-16 |
Date Published | 2016 Jul 14 |
ISSN | 1875-8908 |
Abstract | One of the key research agenda of the field of aging is investigation of presymptomatic Alzheimer's disease (AD). Furthermore, abnormalities in brain glucose metabolism (as measured by FDG-PET) have been reported among cognitively normal elderly persons. However, little is known about the association of FDG-PET abnormalities with neuropsychiatric symptoms (NPS) in a population-based setting. Thus, we conducted a cross-sectional study derived from the ongoing population-based Mayo Clinic Study of Aging in order to examine the association between brain glucose metabolism and NPS among cognitively normal (CN) persons aged > 70 years. Participants underwent FDG-PET and completed the Neuropsychiatric Inventory Questionnaire (NPI-Q), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI). Cognitive classification was made by an expert consensus panel. We conducted multivariable logistic regression analyses to compute odds ratios (OR) and 95% confidence intervals after adjusting for age, sex, and education. For continuous variables, we used linear regression and Spearman rank-order correlations. Of 668 CN participants (median 78.1 years, 55.4% males), 205 had an abnormal FDG-PET (i.e., standardized uptake value ratio |
DOI | 10.3233/JAD-160326 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 27447426 |
PubMed Central ID | PMC4981903 |
Grant List | K01 AG028573 / AG / NIA NIH HHS / United States K01 MH068351 / MH / NIMH NIH HHS / United States R01 AG034676 / AG / NIA NIH HHS / United States U01 AG006786 / AG / NIA NIH HHS / United States |