Title | Cholesteryl Ester Transfer Protein Intimately Involved in Dyslipidemia-Related Susceptibility to Cognitive Deficits in Type 2 Diabetic Patients. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Sun, J, Cai, R, Huang, R, Wang, P, Tian, S, Sun, H, Xia, W, Wang, S |
Journal | J Alzheimers Dis |
Volume | 54 |
Issue | 1 |
Pagination | 175-84 |
Date Published | 2016 Aug 01 |
ISSN | 1875-8908 |
Abstract | BACKGROUND: Cholesteryl ester transfer protein (CETP) is involved in diabetic dyslipidemia. OBJECTIVE: We aim to test the hypothesis that CETP might be of importance in mediating dyslipidemia-related susceptibility to cognitive deficits in diabetic patients. METHODS: We recruited 190 type 2 diabetic patients and divided them into two groups according to the Montreal Cognitive Assessment (MoCA) score. The association between CETP and cognitive decline was analyzed with logistic regression and stratification. RESULTS: There were 110 diabetic patients with mild cognition impairment (MCI) and 80 healthy cognition subjects as controls. Dyslipidemia is more common among diabetic patients with MCI; they had a significant increase of serum CETP concentrations, which was negatively correlated with MoCA (r = -0.638; p CONCLUSIONS: CETP was intimately involved in dyslipidemia-related susceptibility to cognitive decline, especially memory function in type 2 diabetic patients. |
DOI | 10.3233/JAD-160053 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 27497473 |