Journal of Alzheimer's Disease
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Home > Heart Rate Spectra Confirm the Presence of Autonomic Dysfunction in Dementia Patients.

TitleHeart Rate Spectra Confirm the Presence of Autonomic Dysfunction in Dementia Patients.
Publication TypeJournal Article
Year of Publication2016
AuthorsStruhal, W, Mahringer, C, Lahrmann, H, Mörtl, C, Buhl, P, Huemer, M, Ransmayr, G
JournalJ Alzheimers Dis
Volume54
Issue2
Pagination657-67
Date Published2016 Sep 06
ISSN1875-8908
Abstract

Recent data suggest autonomic dysfunction in patients suffering dementia. This study evaluated autonomic modulation in dementia patients with and without autonomic involvement, employing ECG spectral analysis in the time-frequency domain (wavelet transform) in supine resting and head-up tilt (HUT) position. Thirty-six patients were prospectively evaluated at the Department of Neurology and Psychiatry, General Hospital of the City of Linz, between 2009 and 2014. A standard cardiovascular autonomic test series (Ewing battery) was performed to screen for autonomic dysfunction. The Ewing battery diagnoses were used as reference standard and compared to the diagnostic results obtained by spectral analysis (time-frequency domain) of ECG recordings. Based on the Ewing battery results, 14 patients suffered autonomic dysfunction, while 22 did not. Time frequency domain was accessed by using the continuous wavelet transformation (CWT) with an analytical Morlet mother wavelet in supine resting and HUT position. Within each cohort the modification of spectral components from supine resting to HUT was analyzed reflecting the autonomic modulation. For patients without autonomic dysfunction, a significant increase of autonomic modulation was detected by wavelet transformed ECG recordings (8%, p 

DOI10.3233/JAD-160084
Alternate JournalJ. Alzheimers Dis.
PubMed ID27567816
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Source URL: https://www.j-alz.com/content/heart-rate-spectra-confirm-presence-autonomic-dysfunction-dementia-patients