| Title | Characterization of Alzheimer's Disease and Mild Cognitive Impairment in Older Adults in Panama. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Villarreal, AE, Grajales, S, O'Bryant, SE, Edwards, M, López, L, Montalván, A, Britton, GB |
| Corporate Authors | Panama Aging Research Initiative (PARI) |
| Journal | J Alzheimers Dis |
| Volume | 54 |
| Issue | 3 |
| Pagination | 897-901 |
| Date Published | 2016 Oct 04 |
| ISSN | 1875-8908 |
| Abstract | Research on age-related cognitive impairment is scarce in Central America. We report factors associated with cognitive impairment among a sample of older adults in Panama diagnosed with Alzheimer's disease (AD, n = 31), mild cognitive impairment (MCI, n = 43), or no cognitive impairment (controls, n = 185). Apolipoprotein E (ApoE) genotype was assessed in a subset of cases (n = 135). Age (OR = 2.53, 95% CI = 1.03-6.17) and ApoE ɛ4 (OR = 5.14, 95% CI = 2.11-12.52) were significantly related to cognitive impairment (AD/MCI combined). Results underscore the potential of genetic screening in Panama for identifying those at risk of dementia. |
| DOI | 10.3233/JAD-160402 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 27567849 |
