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Home > Elevated mRNA Expression and Low Methylation of SNCA in Japanese Alzheimer's Disease Subjects.

TitleElevated mRNA Expression and Low Methylation of SNCA in Japanese Alzheimer's Disease Subjects.
Publication TypeJournal Article
Year of Publication2016
AuthorsYoshino, Y, Mori, T, Yoshida, T, Yamazaki, K, Ozaki, Y, Sao, T, Funahashi, Y, Iga, J-I, Ueno, S-I
JournalJ Alzheimers Dis
Volume54
Issue4
Pagination1349-1357
Date Published2016 Oct 18
ISSN1875-8908
Abstract

Despite the continuing debate about the amyloid hypothesis in Alzheimer's disease (AD), the precise pathogenesis is still unclear. Mixed pathology is common and multiple different protein aggregates are seen in human postmortem brains. Aggregates consisting of the alpha-synuclein protein encoded by the Synuclein Alpha gene (SCNA) are common in both dementia with Lewy bodies and AD. We examined SNCA mRNA expression and methylation rates of the CpG island at intron 1 of SNCA in peripheral leukocytes in 50 AD and age- and sex-matched control subjects to verify whether alpha-synuclein pathology affects the AD pathogenesis. SNCA mRNA expression in AD subjects was significantly higher than that in control subjects (1.62±0.73 versus 0.98±0.50, p 

DOI10.3233/JAD-160430
Alternate JournalJ. Alzheimers Dis.
PubMed ID27567856
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Source URL: https://www.j-alz.com/content/elevated-mrna-expression-and-low-methylation-snca-japanese-alzheimers-disease-subjects