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Home > Associations between Performance on an Abbreviated CogState Battery, Other Measures of Cognitive Function, and Biomarkers in People at Risk for Alzheimer's Disease.

TitleAssociations between Performance on an Abbreviated CogState Battery, Other Measures of Cognitive Function, and Biomarkers in People at Risk for Alzheimer's Disease.
Publication TypeJournal Article
Year of Publication2016
AuthorsRacine, AM, Clark, LR, Berman, SE, Koscik, RL, Mueller, KD, Norton, D, Nicholas, CR, Blennow, K, Zetterberg, H, Jedynak, B, Bilgel, M, Carlsson, CM, Christian, BT, Asthana, S, Johnson, SC
JournalJ Alzheimers Dis
Volume54
Issue4
Pagination1395-1408
Date Published2016 Oct 18
ISSN1875-8908
Abstract

It is not known whether computerized cognitive assessments, like the CogState battery, are sensitive to preclinical cognitive changes or pathology in people at risk for Alzheimer's disease(AD). In 469 late middle-aged participants from the Wisconsin Registry for Alzheimer's Prevention(mean age 63.8±7 years at testing; 67% female; 39% APOE4+), we examined relationships between a CogState abbreviated battery(CAB) of seven tests and demographic characteristics, traditional paper-based neuropsychological tests as well as a composite cognitive impairment index, cognitive impairment status(determined by consensus review), and biomarkers for amyloid and tau(CSF phosphorylated-tau/Aβ42 and global PET-PiB burden) and neural injury(CSF neurofilament light protein). CSF and PET-PiB were collected in n = 71 and n = 91 participants, respectively, approximately four years prior to CAB testing. For comparison, we examined three traditional tests of delayed memory in parallel. Similar to studies in older samples, the CAB was less influenced by demographic factors than traditional tests. CAB tests were generally correlated with most paper-based cognitive tests examined and mapped onto the same cognitive domains. Greater composite cognitive impairment index was associated with worse performance on all CAB tests. Cognitively impaired participants performed significantly worse compared to normal controls on all but one CAB test. Poorer One Card Learning test performance was associated with higher levels of CSF phosphorylated-tau/Aβ42. These results support the use of the CogState battery as measures of early cognitive impairment in studies of people at risk for AD.

DOI10.3233/JAD-160528
Alternate JournalJ. Alzheimers Dis.
PubMed ID27589532
PubMed Central IDPMC5074904
Grant ListR01 AG037639 / AG / NIA NIH HHS / United States
P30 HD003352 / HD / NICHD NIH HHS / United States
UL1 TR000427 / TR / NCATS NIH HHS / United States
T32 GM008692 / GM / NIGMS NIH HHS / United States
T32 GM007507 / GM / NIGMS NIH HHS / United States
R01 AG027161 / AG / NIA NIH HHS / United States
UL1 RR025011 / RR / NCRR NIH HHS / United States
R01 AG021155 / AG / NIA NIH HHS / United States
T32 AG000213 / AG / NIA NIH HHS / United States
P50 AG033514 / AG / NIA NIH HHS / United States
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Source URL: https://www.j-alz.com/content/associations-between-performance-%C2%A0%C2%A0abbreviated-cogstate-battery-other%C2%A0measures-cognitive