Journal of Alzheimer's Disease
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Home > Visual Rating of Posterior Atrophy as a Marker of Progression to Dementia in Mild Cognitive Impairment Patients.

TitleVisual Rating of Posterior Atrophy as a Marker of Progression to Dementia in Mild Cognitive Impairment Patients.
Publication TypeJournal Article
Year of Publication2017
AuthorsKim, H-R, Park, YHo, Jang, J-W, Park, SYoung, Wang, MJeong, Baek, MJae, Kim, BJoon, Ahn, S, Kim, SY
JournalJ Alzheimers Dis
Volume55
Issue1
Pagination137-146
Date Published2017
ISSN1875-8908
Abstract

BACKGROUND: Although medial temporal atrophy (MTA) is a useful imaging marker of the progression to dementia in mild cognitive impairment (MCI), substantial numbers of MCI patients without MTA still progress to dementia.

OBJECTIVE: We investigated whether visual ratings of posterior atrophy (PA) on magnetic resonance imaging show independent predictive value for the progression to dementia in MCI patients.

METHODS: This was a retrospective cohort study of elderly patients who visited Seoul National University Bundang Hospital between 2004 and 2012. A total of 148 patients who were initially diagnosed with MCI were followed for up to 3 years (median 22 months) to determine whether they progressed to dementia. We used 4-point and 5-point visual rating scales to assess PA and MTA, respectively. PA and MTA scores were dichotomized into normal (no atrophy) or abnormal (atrophy) in each patient. We performed a Cox regression analysis to examine the hazard ratios (HRs) of PA and MTA for the progression to dementia with adjustment for age, APOEɛ4 allele status, and baseline Mini-Mental State Examination score.

RESULTS: Among the study population, 47 patients progressed to dementia. Visual assessment of the MRI scans revealed that 67 patients (45.3%) showed PA, whereas 85 patients (57.3%) showed MTA. The HRs with 95% confidence intervals for PA and MTA were 2.516 (1.244-5.091) and 4.238 (1.680-10.687), respectively. The predictive values of visually assessed PA and MTA remained significant, independent of the covariates.

CONCLUSION: Visual assessment of PA has independent predictive value for progression to dementia in MCI patients.

DOI10.3233/JAD-160339
Alternate JournalJ. Alzheimers Dis.
PubMed ID27636842
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