| Title | Aortic Valve Calcification and the Risk of dementia: A Population-Based Study. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Wolters, FJ, Bos, D, Vernooij, MW, Franco, OH, Hofman, A, Koudstaal, PJ, van der Lugt, A, M Ikram, A |
| Corporate Authors | Heart-Brain Connection collaborative research group |
| Journal | J Alzheimers Dis |
| Volume | 55 |
| Issue | 3 |
| Pagination | 893-897 |
| Date Published | 2017 |
| ISSN | 1875-8908 |
| Abstract | The association of aortic valve calcification (AVC) with dementia remains unknown. In 2,428 non-demented participants from the population-based Rotterdam Study, we investigated the association of CT-assessed AVC with risk of dementia and cognitive decline. AVC was present in 33.1% of the population. During a median follow-up of 9.3 years, 160 participants developed dementia. We found no association between presence of AVC and risk of all-cause dementia [hazard ratio (HR): 0.89 (95% confidence interval (CI):0.63;1.26)]. Presence of AVC was not associated with cognitive decline on any of the cognitive tests, nor with a measure of global cognition. |
| DOI | 10.3233/JAD-160871 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 27767996 |
