Journal of Alzheimer's Disease
Published on Journal of Alzheimer's Disease (https://www.j-alz.com)

Home > Serum SHBG Levels are not Associated with Longitudinal Cognitive Decline in Mild Cognitive Impairment.

TitleSerum SHBG Levels are not Associated with Longitudinal Cognitive Decline in Mild Cognitive Impairment.
Publication TypeJournal Article
Year of Publication2017
AuthorsLin, KAmy, Rundel, C, P Doraiswamy, M
Corporate AuthorsAlzheimer’s Disease Neuroimaging Initiative
JournalJ Alzheimers Dis
Volume55
Issue3
Pagination1123-1130
Date Published2017
ISSN1875-8908
Abstract

BACKGROUND: Prior studies have noted gender differences in cognition, imaging, and pathological markers in mild cognitive impairment (MCI) subjects. Sex hormone-binding globulin (SHBG), a major controlling factor in the proportion of bioavailable versus bound testosterone and estrogen, has been proposed to contribute to links between hormones and dementia, but has not yet been investigated fully in a prospective biomarker trial.

OBJECTIVE: This study examined whether, among subjects with MCI, SHBG levels predict future rate of cognitive decline.

METHODS: We examine the effect of gender on cognitive decline and factors modulating potential gender differences in 378 MCI subjects (134 females, 244 males) in the Alzheimer's Disease Neuroimaging Initiative-1 (ADNI-1), followed for up to 8 years (mean ± SE, 4.0 ± 0.1 years). Cognition was assessed using the ADAS-cog-11. Multivariate models examined the effect of gender covarying for age, ApoE4, baseline cognition, years of education, and SHBG levels.

RESULTS: MCI women declined significantly faster than men in cognition over the follow up period. Baseline SHBG levels differed significantly between men and women (p 

CONCLUSION: SHBG levels did not influence the rate of cognitive decline in MCI. Further studies to confirm these findings and uncover other potential mechanisms of gender differences in the risk for AD may be warranted.

DOI10.3233/JAD-160513
Alternate JournalJ. Alzheimers Dis.
PubMed ID27767986
E-mail Icon
Comment Icon
  • Comment
Bookmark Icon Bookmark Recommend Icon Recommend Follow Icon Follow
  • Comment
| Bookmark | Recommend | Follow

Source URL: https://www.j-alz.com/content/serum-shbg-levels-are-not-associated-longitudinal-cognitive-decline-mild-cognitive