| Title | Sleep-Wake Profile in Dementia with Lewy Bodies, Alzheimer's Disease, and Normal Aging. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Cagnin, A, Fragiacomo, F, Camporese, G, Turco, M, Bussè, C, Ermani, M, Montagnese, S |
| Journal | J Alzheimers Dis |
| Volume | 55 |
| Issue | 4 |
| Pagination | 1529-1536 |
| Date Published | 2017 |
| ISSN | 1875-8908 |
| Abstract | BACKGROUND: Alterations of the sleep-wake cycle are common features of neurodegenerative dementia. OBJECTIVES: To study differences in sleep-wake profiles in dementia with Lewy bodies (DLB), Alzheimer's disease (AD), and healthy controls. METHODS: 30 DLB and 32 AD patients, and 33 healthy elderly participants were studied. Patients were evaluated for global cognitive impairment, extrapyramidal signs, fluctuations of attention, and behavioral disorders. A comprehensive sleep-wake profile was obtained including a set of questionnaires [Pittsburgh Sleep Quality Index (PSQI), REM Sleep Behavior Disorder Single-Question screen (RBD1Q), Epworth Sleepiness Scale (ESS)] and 12-day sleep diaries. RESULTS: Patients were matched for age, gender, and disease severity. DLB patients showed more severe daytime somnolence/dysfunction due to somnolence, and a higher proportion of RBD-like symptoms (70%) compared to AD and controls (p DISCUSSION: RBD and daytime fluctuations of attention may coexist in DLB and even reciprocally potentiate each other. Self-reports of sleep quality may lead to an underestimation of sleep disturbances in AD, possibly influenced by anosognosia, compared to normal elderly individuals who complain mainly of insomnia. |
| DOI | 10.3233/JAD-160385 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 27886007 |
