Title | Physical Exercise Moderates the Relationship of Apolipoprotein E (APOE) Genotype and Dementia Risk: A Population-Based Study. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Fenesi, B, Fang, H, Kovacevic, A, Oremus, M, Raina, P, Heisz, JJ |
Journal | J Alzheimers Dis |
Volume | 56 |
Issue | 1 |
Pagination | 297-303 |
Date Published | 2017 |
ISSN | 1875-8908 |
Abstract | Genetics and lifestyle independently determine dementia risk, but the interaction is unclear. We assessed the interactive relationship of apolipoprotein E (APOE) genotype and physical exercise on dementia risk over a 5-year period in 1,646 older adults from the Canadian Study of Health and Aging who were dementia-free at baseline. Physical exercise moderated the relationship between genotype and dementia (p |
DOI | 10.3233/JAD-160424 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 27911292 |