Journal of Alzheimer's Disease
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Home > Face-Name Associative Recognition Deficits in Subjective Cognitive Decline and Mild Cognitive Impairment.

TitleFace-Name Associative Recognition Deficits in Subjective Cognitive Decline and Mild Cognitive Impairment.
Publication TypeJournal Article
Year of Publication2017
AuthorsPolcher, A, Frommann, I, Koppara, A, Wolfsgruber, S, Jessen, F, Wagner, M
JournalJ Alzheimers Dis
Volume56
Issue3
Pagination1185-1196
Date Published2017
ISSN1875-8908
Abstract

BACKGROUND: There is a need for more sensitive neuropsychological tests to detect subtle cognitive deficits emerging in the preclinical stage of Alzheimer's disease (AD). Associative memory is a cognitive function supported by the hippocampus and affected early in the process of AD.

OBJECTIVE: We developed a short computerized face-name associative recognition test (FNART) and tested whether it would detect memory impairment in memory clinic patients with mild cognitive impairment (MCI) and subjective cognitive decline (SCD).

METHODS: We recruited 61 elderly patients with either SCD (n = 32) or MCI (n = 29) and 28 healthy controls (HC) and compared performance on FNART, self-reported cognitive deterioration in different domains (ECog-39), and, in a reduced sample (n = 46), performance on the visual Paired Associates Learning of the CANTAB battery.

RESULTS: A significant effect of group on FNART test performance in the total sample was found (p 

CONCLUSIONS: Associative memory is substantially impaired in memory clinic patients with SCD and correlates specifically with memory complaints at this putative preclinical stage of AD. Further studies will need to examine the predictive validity of the FNART in SCD patients with regard to longitudinal (i.e., conversion to MCI/AD) and biomarker outcomes.

DOI10.3233/JAD-160637
Alternate JournalJ. Alzheimers Dis.
PubMed ID28106560
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Source URL: https://www.j-alz.com/content/face-name-associative-recognition-deficits-subjective-cognitive-decline-and-mild-cognitive