Title | Effect of Spinal Manometers on Cerebrospinal Fluid Amyloid-β Concentration. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Toombs, J, Foiani, MS, Paterson, RW, Heslegrave, A, Wray, S, Schott, JM, Fox, NC, Lunn, MP, Blennow, K, Zetterberg, H |
Journal | J Alzheimers Dis |
Volume | 56 |
Issue | 3 |
Pagination | 885-891 |
Date Published | 2017 |
ISSN | 1875-8908 |
Abstract | The effect of spinal manometers on cerebrospinal fluid (CSF) amyloid-β (Aβ) concentration was investigated. Pooled human CSF samples were divided in two, one half passed through a manometer into a collection tube, the other transferred directly to a collection tube. CSF was analyzed for Aβ38/40/42 using an electrochemiluminescence immunoassay. Relative to control, use of a manometer decreased Aβ38/40/42 concentration by 5.6% (±1.5SE), 4.4% (±1.7SE), and 4.3% (±2.4SE), respectively. The ratios of Aβ42 :40, Aβ42 :38, and Aβ40 :38 were not affected by manometer treatment. Factors which artificially lower CSF Aβ concentrations are relevant to clinical diagnosis for AD and study design. |
DOI | 10.3233/JAD-161126 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 28059797 |
Grant List | MR/L023784/1 / / Medical Research Council / United Kingdom |