| Title | Silicic Acid and Beer Consumption Reverses the Metal Imbalance and the Prooxidant Status Induced by Aluminum Nitrate in Mouse Brain. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | González-Muñoz, MJosé, Garcimartán, A, Meseguer, I, Mateos-Vega, CJosé, Orellana, JMaría, Peña-Fernández, A, Benedí, J, Sánchez-Muniz, FJ |
| Journal | J Alzheimers Dis |
| Volume | 56 |
| Issue | 3 |
| Pagination | 917-927 |
| Date Published | 2017 |
| ISSN | 1875-8908 |
| Abstract | BACKGROUND: Emerging evidence suggests that by affecting mineral balance, aluminum (Al) may enhance some events associated with neurodegenerative diseases. AIM: To examine the effect of Al(NO3)3 exposure on brain Al, cooper (Cu), iron (Fe), magnesium (Mg), manganese (Mn), silicon (Si), and zinc (Zn) levels, and the metal-change implication in brain oxidant and inflammatory status. METHODS: Four groups of six-week-old male NMRI mice were treated for three months: i) controls, administrated with deionized water; ii) Al, which received Al(NO3)3; iii) Al+silicic acid, which were given Al(NO3)3 plus silicic acid; and iv) Al+beer, which received Al(NO3)3 plus beer. RESULTS: Brain Al and TBARS levels and TNFα and GPx expressions increased, while Cu, Mn, and Zn levels, and catalase and CuZn-SOD expression decreased (at least, p CONCLUSION: Administration of Al(NO3)3 induced metal imbalance, inflammation, and antioxidant status impairment in the brain. Those effects were blocked to a significant extent by silicic acid and beer administration. |
| DOI | 10.3233/JAD-160972 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 28059788 |
