| Title | Comparing Approaches to Optimize Cut-off Scores for Short Cognitive Screening Instruments in Mild Cognitive Impairment and Dementia. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | O'Caoimh, R, Gao, Y, Svendovski, A, Gallagher, P, Eustace, J, D Molloy, W |
| Journal | J Alzheimers Dis |
| Volume | 57 |
| Issue | 1 |
| Pagination | 123-133 |
| Date Published | 2017 |
| ISSN | 1875-8908 |
| Abstract | BACKGROUND: Although required to improve the usability of cognitive screening instruments (CSIs), the use of cut-off scores is controversial yet poorly researched. OBJECTIVE: To explore cut-off scores for two short CSIs: the Standardized Mini-Mental State Examination (SMMSE) and Quick Mild Cognitive Impairment (Qmci) screen, describing adjustments in scores for diagnosis (MCI or dementia), age (≤, >75 years), and education ( METHODS: Pooled analysis of assessments from patients attending memory clinics in Canada between 1999-2010 : 766 with mild cognitive impairment (MCI) and 1,746 with dementia, and 875 normal controls. RESULTS: The Qmci was more accurate than the SMMSE in differentiating controls from MCI or cognitive impairment (MCI and dementia). Employing the maximal accuracy approach, the optimal SMMSE cut-off for cognitive impairment was CONCLUSION: Caution should be exercised selecting cut-offs as these differ by age, education, and method of derivation, with the extent of adjustment varying between CSIs. |
| DOI | 10.3233/JAD-161204 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 28222528 |
| PubMed Central ID | PMC5345649 |
