Title | Differential Regional Distribution of Juxtacortical White Matter Signal Abnormalities in Aging and Alzheimer's Disease. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Lindemer, ER, Greve, DN, Fischl, B, Augustinack, JC, Salat, DH |
Corporate Authors | Alzheimer’s Disease Neuroimaging Initiative |
Journal | J Alzheimers Dis |
Volume | 57 |
Issue | 1 |
Pagination | 293-303 |
Date Published | 2017 |
ISSN | 1875-8908 |
Abstract | BACKGROUND: White matter signal abnormalities (WMSA) (also known as 'hyperintensities') on MRI are commonly seen in normal aging and increases have been noted in Alzheimer's disease (AD), but whether there is a spatial specificity to these increases is unknown. OBJECTIVE: To discern whether or not there is a spatial pattern of WMSA in the brains of individuals with AD that differs from those who exhibit cognitively healthy aging. METHOD: Structural MRI data from the Alzheimer's Disease Neuroimaging Initiative public database were used to quantify WMSA in 35 regions of interest (ROIs). Regional measures were compared between cognitively healthy older controls (OC; n = 107) and individuals with a clinical diagnosis of AD (n = 127). Regional WMSA volume was also assessed in individuals with mild cognitive impairment (MCI; n = 74) who were 6, 12, and 24 months away from AD conversion. RESULTS: WMSA volume was significantly greater in AD compared to OC in 24 out of 35 ROIs after controlling for age, and nine were significantly higher after normalizing for total WMSA. Regions with greater WMSA volume in AD included rostral frontal, inferior temporal, and inferior parietal WM. In MCI, frontal and temporal regions demonstrated significantly greater WMSA volume with decreasing time-to-AD-conversion. DISCUSSION: Individuals with AD have greater regional volume of WMSA compared to OC regardless of age or total WMSA volume. Accumulation of regional WMSA is linked to time to AD conversion in individuals with MCI. These findings indicate WMSA is an important pathological component of AD development. |
DOI | 10.3233/JAD-161057 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 28222518 |
PubMed Central ID | PMC5534349 |
Grant List | U01 MH093765 / MH / NIMH NIH HHS / United States R01 NS070963 / NS / NINDS NIH HHS / United States U01 NS086625 / NS / NINDS NIH HHS / United States R21 EB018907 / EB / NIBIB NIH HHS / United States R01 AG016495 / AG / NIA NIH HHS / United States R21 DK108277 / DK / NIDDK NIH HHS / United States U01 AG024904 / AG / NIA NIH HHS / United States S10 RR019307 / RR / NCRR NIH HHS / United States T32 EB001680 / EB / NIBIB NIH HHS / United States R01 AG008122 / AG / NIA NIH HHS / United States T90 DA022759 / DA / NIDA NIH HHS / United States R90 DA023427 / DA / NIDA NIH HHS / United States R01 EB019956 / EB / NIBIB NIH HHS / United States R21 NS072652 / NS / NINDS NIH HHS / United States S10 RR023043 / RR / NCRR NIH HHS / United States R01 EB006758 / EB / NIBIB NIH HHS / United States P41 EB015896 / EB / NIBIB NIH HHS / United States R01 NS083534 / NS / NINDS NIH HHS / United States S10 RR023401 / RR / NCRR NIH HHS / United States R01 NR010827 / NR / NINR NIH HHS / United States |