Journal of Alzheimer's Disease
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Home > Cognitive Composites Domain Scores Related to Neuroimaging Biomarkers within Probable-Amnestic Mild Cognitive Impairment-Storage Subtype.

TitleCognitive Composites Domain Scores Related to Neuroimaging Biomarkers within Probable-Amnestic Mild Cognitive Impairment-Storage Subtype.
Publication TypeJournal Article
Year of Publication2017
AuthorsEspinosa, A, Alegret, M, Pesini, P, Valero, S, Lafuente, A, Buendia, M, San José, I, Ibarria, M, Tejero, MA, Giménez, J, Ruiz, S, Hernandez, I, Pujadas, F, Martínez-Lage, P, Munuera, J, Arbizu, J, Tárraga, L, Hendrix, SB, Ruiz, A, Becker, JT, Landau, SM, Sotolongo-Grau, O, Sarasa, M, Boada, M
Corporate AuthorsAB255 Study Group, Alzheimer’s Disease Neuroimaging Initiative
JournalJ Alzheimers Dis
Volume57
Issue2
Pagination447-459
Date Published2017
ISSN1875-8908
Abstract

The probable-amnestic (Pr-a) mild cognitive impairment (MCI)-storage subtype is a phenotype with 8.5 times more risk of conversion to dementia, mainly Alzheimer's disease (AD), than the possible non-amnestic (Pss-na) MCI. The aim of this study was to find the optimized cognitive composites (CCs) domain scores most related to neuroimaging biomarkers within Pr-aMCI-storage subtype patients. The Fundació ACE (ACE) study with 20 Pr-aMCI-storage subtype subjects (MCI) were analyzed. All subjects underwent a neuropsychological assessment, a structural MRI, FDG-PET, and PIB-PET. The adjusted hippocampal volume (aHV) on MRI, the standard uptake value ratio (SUVR) on FDG-PET and PIB-PET SUVR measures were analyzed. The construction of the CCs domain scores, and the aHV on MRI and FDG-PET SUVR measures, were replicated in the parental AB255 study database (n = 133 MCI). Partial correlations adjusted by age, gender, and education were calculated with the associated p-value among every CC domain score and the neuroimaging biomarkers. The results were replicated in the "MCI due to AD" with memory storage impairments from ADNI. Delayed Recall CC domain score was significantly correlated with PIB-PET SUVR (β= -0.61, p = 0.003) in the ACE study and also with aHV on MRI (β= 0.27, p = 0.01) and FDG-PET SUVR (β= 0.27, p = 0.01) in the AB255 study. After a median survival time of 20.6 months, 85% from the ACE MCI converted to AD. The replication of our results in the ADNI dataset also confirmed our findings. Delayed Recall is the CC domain score best correlated with neuroimaging biomarkers associated with prodromal AD diagnosis.

DOI10.3233/JAD-161223
Alternate JournalJ. Alzheimers Dis.
PubMed ID28269787
PubMed Central IDPMC5366247
Grant ListP50 AG005133 / AG / NIA NIH HHS / United States
U01 AG024904 / AG / NIA NIH HHS / United States
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Source URL: https://www.j-alz.com/content/cognitive-composites-domain-scores-related-neuroimaging-biomarkers-within-probable-amnestic