| Title | Combined Dual-Task Gait Training and Aerobic Exercise to Improve Cognition, Mobility, and Vascular Health in Community-Dwelling Older Adults at Risk for Future Cognitive Decline1. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Gregory, MA, Silva, NCBoa Sort, Gill, DP, McGowan, CL, Liu-Ambrose, T, J Shoemaker, K, Hachinski, V, Holmes, J, Petrella, RJ |
| Journal | J Alzheimers Dis |
| Volume | 57 |
| Issue | 3 |
| Pagination | 747-763 |
| Date Published | 2017 |
| ISSN | 1875-8908 |
| Keywords | Aged, Aged, 80 and over, Analysis of Variance, Blood Pressure, Blood Pressure Monitoring, Ambulatory, Carotid Intima-Media Thickness, Cognition Disorders, Exercise, Exercise Therapy, Female, Follow-Up Studies, Gait, Humans, Independent Living, Male, Middle Aged, Neuropsychological Tests |
| Abstract | This 6-month experimental case series study investigated the effects of a dual-task gait training and aerobic exercise intervention on cognition, mobility, and cardiovascular health in community-dwelling older adults without dementia. Participants exercised 40 min/day, 3 days/week for 26 weeks on a Biodex GaitTrainer2 treadmill. Participants were assessed at baseline (V0), interim (V1: 12-weeks), intervention endpoint (V2: 26-weeks), and study endpoint (V3: 52-weeks). The study outcomes included: cognition [executive function (EF), processing speed, verbal fluency, and memory]; mobility: usual & dual-task gait (speed, step length, and stride time variability); and vascular health: ambulatory blood pressure, carotid arterial compliance, and intima-media thickness (cIMT). Fifty-six participants [age: 70(6) years; 61% female] were included in this study. Significant improvements following the exercise program (V2) were observed in cognition: EF (p = 0.002), processing speed (p |
| DOI | 10.3233/JAD-161240 |
| Alternate Journal | J. Alzheimers Dis. |
| PubMed ID | 28304305 |
| Grant List | 201713 / / CIHR / Canada |
